| Controlled delivery of a hydrophilic drug from a biodegradable microsphere system by supercritical anti-solvent precipitation technique. | |
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MedLine Citation:
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PMID: 17123918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to prepare microspheres loaded with hydrophilic drug, bupivacaine HCl using poly(D,L-lactic-co-glycolic acid) (PLGA) and poly(L-lactic acid) (PLLA). Microspheres were prepared with varying the PLGA/PLLA ratio with two different levels of bupivacaine HCl (5 and 10%) using a supercritical anti-solvent (SAS) technique. Microspheres ranging from 4-10 microm in geometric mean diameter could be prepared, with high loading efficiency. Powder X-ray diffraction (PXRD) revealed that bupivacaine HCl retained its crystalline state within the polymer and was present as a dispersion within the polymer phase after SAS processing. The release of bupivacaine HCl from biodegradable polymer microspheres was rapid up to 4 h, thereafter bupivacaine HCl was continuously and slowly released for at least 7 days according to the PLGA/PLLA ratio and the molecular weight of PLLA. |
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Authors:
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S Lee; M S Kim; J S Kim; H J Park; J S Woo; B C Lee; S J Hwang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of microencapsulation Volume: 23 ISSN: 0265-2048 ISO Abbreviation: J Microencapsul Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-11-24 Completed Date: 2007-11-20 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8500513 Medline TA: J Microencapsul Country: England |
Other Details:
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Languages: eng Pagination: 741-9 Citation Subset: IM |
Affiliation:
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National Research Lab of Pharmaceutical Technology, College of Pharmacy, Chungnam National University, Daejeon, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorbable Implants Biocompatible Materials / chemistry Bupivacaine / administration & dosage* Chemical Precipitation Delayed-Action Preparations / administration & dosage Drug Compounding / methods Hydrochloric Acid / chemistry Lactic Acid / chemistry Microscopy, Electron, Scanning Microspheres* Particle Size Polyglycolic Acid / chemistry Polymers / chemistry Solvents / chemistry Surface Properties X-Ray Diffraction |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Delayed-Action Preparations; 0/Polymers; 0/Solvents; 0/polylactic acid-polyglycolic acid copolymer; 2180-92-9/Bupivacaine; 26009-03-0/Polyglycolic Acid; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid; 7647-01-0/Hydrochloric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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