| Controlled clinical trials in cancer research. | |
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MedLine Citation:
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PMID: 9073046 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Knowledge of important aspects of the design and analysis of clinical trials is essential to clinical researchers and readers of medical literature. A brief description of proper trial design, including the contents of a trial protocol, as well as different strategies to avoid bias, is given. The concept of p-values is explained, and some commonly used statistical analysis methods are mentioned. Statistical power is defined, and two useful formulas and examples of estimating sample size are presented. The correct interpretation of trial results is emphasized, and misinterpretations and errors that frequently occur are dealt with. Various issues regarding multiple significance testing, such as interim analyses, multiple endpoints, and subgroup analyses, are addressed. |
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Authors:
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E Skovlund |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta oncologica (Stockholm, Sweden) Volume: 35 Suppl 8 ISSN: 0284-186X ISO Abbreviation: Acta Oncol Publication Date: 1996 |
Date Detail:
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Created Date: 1997-04-11 Completed Date: 1997-04-11 Revised Date: 2009-05-12 |
Medline Journal Info:
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Nlm Unique ID: 8709065 Medline TA: Acta Oncol Country: NORWAY |
Other Details:
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Languages: eng Pagination: 27-33 Citation Subset: IM |
Affiliation:
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University of Oslo, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Controlled Clinical Trials as Topic
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methods* Double-Blind Method Neoplasms / therapy* Patient Selection Random Allocation Research Design Sample Size Statistics as Topic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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