Document Detail

Controlled clinical trials in cancer research.
MedLine Citation:
PMID:  9073046     Owner:  NLM     Status:  MEDLINE    
Knowledge of important aspects of the design and analysis of clinical trials is essential to clinical researchers and readers of medical literature. A brief description of proper trial design, including the contents of a trial protocol, as well as different strategies to avoid bias, is given. The concept of p-values is explained, and some commonly used statistical analysis methods are mentioned. Statistical power is defined, and two useful formulas and examples of estimating sample size are presented. The correct interpretation of trial results is emphasized, and misinterpretations and errors that frequently occur are dealt with. Various issues regarding multiple significance testing, such as interim analyses, multiple endpoints, and subgroup analyses, are addressed.
E Skovlund
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta oncologica (Stockholm, Sweden)     Volume:  35 Suppl 8     ISSN:  0284-186X     ISO Abbreviation:  Acta Oncol     Publication Date:  1996  
Date Detail:
Created Date:  1997-04-11     Completed Date:  1997-04-11     Revised Date:  2009-05-12    
Medline Journal Info:
Nlm Unique ID:  8709065     Medline TA:  Acta Oncol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  27-33     Citation Subset:  IM    
University of Oslo, Norway.
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MeSH Terms
Controlled Clinical Trials as Topic / methods*
Double-Blind Method
Neoplasms / therapy*
Patient Selection
Random Allocation
Research Design
Sample Size
Statistics as Topic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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