Document Detail

Controlled clinical trial of two multidrug regimens with and without rifampin in highly bacilliferous BL/LL south Indian patients: a five-year report.
MedLine Citation:
PMID:  2198314     Owner:  NLM     Status:  MEDLINE    
A controlled clinical trial of two multidrug regimens in multibacillary lepromatous and near-lepromatous patients with a bacterial index (BI) of 2.5 or more was conducted. Patients were randomly allocated to either a two-drug regimen of dapsone plus clofazimine for 60 months or a four-drug regimen of rifampin, isoniazid, dapsone, and clofazimine for the first 3 months and clofazimine plus dapsone for the next 57 months. There was no difference between the rifampin and nonrifampin regimens with respect to the clinical improvement or bacteriological status of the patients at 60 months. Reactive states and neuritis were observed to be equal in the two patient groups.
A Thomas; A Balakrishnan; M Nagarajan; R Prabhakar; S P Tripathy; M Christian; P R Somasundaram
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association     Volume:  58     ISSN:  0148-916X     ISO Abbreviation:  Int. J. Lepr. Other Mycobact. Dis.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-09-04     Completed Date:  1990-09-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8505819     Medline TA:  Int J Lepr Other Mycobact Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  273-80     Citation Subset:  IM    
Tuberculosis Research Centre, Madras, India.
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MeSH Terms
Clofazimine / therapeutic use
Dapsone / therapeutic use
Drug Therapy, Combination
Infant, Newborn
Isoniazid / therapeutic use
Leprostatic Agents / therapeutic use*
Leprosy, Borderline / drug therapy*
Leprosy, Lepromatous / drug therapy*
Randomized Controlled Trials as Topic
Rifampin / therapeutic use*
Reg. No./Substance:
0/Leprostatic Agents; 13292-46-1/Rifampin; 2030-63-9/Clofazimine; 54-85-3/Isoniazid; 80-08-0/Dapsone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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