Document Detail


Controlled clinical studies of nimesulide in the treatment of urogenital inflammation.
MedLine Citation:
PMID:  7506155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two double-blind, randomised studies were conducted to compare the efficacy and tolerability of nimesulide (200 mg/day) with those of placebo or bromeline (240 mg/day). Treatments were administered orally to patients of either sex (aged 19 to 70 years) with acute infection and inflammation of the urogenital tract, and were given concomitantly with antimicrobial therapy for approximately 9 days. In both studies, a clinically significant improvement in symptoms, leading to complete remission, was achieved in most patients treated with nimesulide. Furthermore, treatment with nimesulide resulted in a more rapid improvement in symptoms and complete remission in a greater number of patients than did treatment with bromeline. Both nimesulide and bromeline were well tolerated.
Authors:
T Lotti; V Mirone; C Imbimbo; F Corrado; G Corrado; F Garofalo; I Scaricabarozzi
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Drugs     Volume:  46 Suppl 1     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  1993  
Date Detail:
Created Date:  1994-02-04     Completed Date:  1994-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  144-6     Citation Subset:  IM    
Affiliation:
Clinica Urologica, Università di Napoli, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Bromelains / therapeutic use
Double-Blind Method
Female
Female Urogenital Diseases / drug therapy*
Humans
Inflammation / drug therapy*
Male
Male Urogenital Diseases*
Middle Aged
Sulfonamides / adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Sulfonamides; 51803-78-2/nimesulide; 9001-00-7/Bromelains

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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