| Controlled-Release Basic Fibroblast Growth Factor for Peripheral Artery Disease: Comparison with Autologous Bone Marrow-Derived Stem Cell Transfer. | |
| | |
MedLine Citation:
|
PMID: 21810028 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Objective: We examined the safety and efficacy of controlled-release basic fibroblast growth factor (b-FGF) for peripheral artery disease (PAD), compared with autologous bone marrow mononuclear cell implantation (BMCI). Background: We recently developed a b-FGF-incorporated biodegradable hydrogel that enables slow-releasing drug delivery system. Methods: PAD patients were divided into a b-FGF group (n=10) and BMCI group (n=15). Injection of gelatin hydrogel containing 600 μg b-FGF or BMCI (0.4-5.1×10(10) cell) was performed. Visual analog pain scale (VAS), (99m)technetium-tetrofosmin (Tc-TF) scintigraphy, transcutaneous oxygen tension (TcPO(2)), and ankle-brachial index (ABI) were evaluated before and 4 weeks after each treatment, and 2-year prognosis was determined. Results: VAS (b-FGF 67±15 to 4±5, p<0.01, BMCI 67±42 to 5±9 mm, p<0.01) and TcPO(2) (b-FGF 16±14 to 47±17, p<0.01, BMCI 13±13 to 37±21 mmHg, p<0.01) were significantly improved in both groups. Tc-TF and ABI were not changed. Prognosis was similar between the groups (b-FGF 91%, BMCI 80%, NS). Conclusion: Controlled-release b-FGF is as safe as BMCI, and its efficacy appears to be comparable. Thus, this therapy may be an alternative to BMCI. |
| | |
Authors:
|
Gen Takagi; Masaaki Miyamoto; Shuhei Tara; Ikuyo Takagi; Hitoshi Takano; Masahiro Yasutake; Yasuhiko Tabata; Kyoichi Mizuno |
Related Documents
:
|
2269838 - Subcutaneous release of trigger thumb and fingers in 210 fingers. 18626368 - Suture anchor suspension and fascia lata interposition arthroplasty for basal joint art... 20351198 - Distal semitendinosus ruptures in elite-level athletes: low success rates of nonoperati... 12780908 - Does the need to self-digitate or the presence of a large or nonemptying rectocoele on ... 14627968 - Polyester vs. bovine pericardial patching during carotid endarterectomy: early neurolog... 8318238 - Regional versus general anesthesia for bone marrow harvesting. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-8-2 |
Journal Detail:
|
Title: Tissue engineering. Part A Volume: - ISSN: 1937-335X ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-8-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101466659 Medline TA: Tissue Eng Part A Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1 Division of Regenerative Medicine and Cardiology, Department of Internal Medicine, Nippon Medical School , Tokyo, Japan . |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Distribution of propranolol in periocular tissues: a comparison of topical and systemic administrati...
Next Document: Scaffolds Based Bone Tissue Engineering: The Role of Chitosan.