Document Detail


Controlled exposure to diesel exhaust causes increased nitrite in exhaled breath condensate among subjects with asthma.
MedLine Citation:
PMID:  23001278     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether oxidative/nitrosative stress plays a role in the acute effects of diesel exhaust (DE) on subjects with asthma.
METHODS: In this crossover study, 16 subjects with mild to moderate asthma were exposed to clean filtered air or diluted DE (300 μg/m as PM2.5) for 1 hour with intermittent exercise.
RESULTS: Airway hyperreactivity increased 24 hours after exposure to DE compared with clean filtered air (PC20, 14.9 mg/mL vs 19.7 mg/mL; P = 0.012). Nitrite in exhaled breath condensate was elevated immediately after diesel exposure (P = 0.052) and remained elevated 4 and 24 hours after exposure.
CONCLUSIONS: After exposure to DE, subjects with asthma demonstrated increased airway hyperreactivity and obstruction. Increased nitrite in exhaled breath condensate, in the absence of increased exhaled nitric oxide, suggests a noninflammatory oxidative stress mechanism by which DE affects the lung.
Authors:
Sabiha Hussain; Robert Laumbach; Jakemia Coleman; Hatim Youssef; Kathie Kelly-McNeil; Pamela Ohman-Strickland; Junfeng Zhang; Howard Kipen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine     Volume:  54     ISSN:  1536-5948     ISO Abbreviation:  J. Occup. Environ. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-08     Completed Date:  2013-04-01     Revised Date:  2014-03-14    
Medline Journal Info:
Nlm Unique ID:  9504688     Medline TA:  J Occup Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1186-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Asthma / metabolism*
Breath Tests / methods*
Cross-Over Studies
Exercise / physiology
Female
Humans
Male
Middle Aged
Nitrites / analysis,  metabolism*
Oxidative Stress / physiology
Vehicle Emissions / analysis,  toxicity*
Young Adult
Grant Support
ID/Acronym/Agency:
K08 ES013520/ES/NIEHS NIH HHS; K08ES013520/ES/NIEHS NIH HHS; P30 ES005022/ES/NIEHS NIH HHS; P30ES005022/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Nitrites; 0/Vehicle Emissions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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