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Controlled Cell Proliferation on an Electrochemically Engineered Collagen Scaffold.
MedLine Citation:
PMID:  22213568     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Therapies for corneal disease and injury often rely on artificial implants, but integrating cells into synthetic corneal materials remains a significant challenge. The electrochemically formed collagen-based matrix presented here is non-toxic to cells and controls the proliferation in the corneal fibroblasts seeded onto it. Histology and biomolecular studies show a behavior similar to corneal stromal cells in a native corneal environment. Not only is this result an important first step toward developing a more realistic, multi-component artificial cornea, but it also opens possibilities for using this matrix to control and contain the growth of cells in engineered tissues.
Authors:
Robert Gendron; M Ramesh Kumar; Helene Paradis; Darryl Martin; Nhu Ho; Danielle Gardiner; Erika F Merschrod S; Kristin M Poduska
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-30
Journal Detail:
Title:  Macromolecular bioscience     Volume:  -     ISSN:  1616-5195     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135941     Medline TA:  Macromol Biosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, NL, A1B 3V6 Canada. rgendron@mun.ca.
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