Document Detail


Controlled attenuation parameter (CAP): a novel VCTE™ guided ultrasonic attenuation measurement for the evaluation of hepatic steatosis: preliminary study and validation in a cohort of patients with chronic liver disease from various causes.
MedLine Citation:
PMID:  20870345     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
There is a need for noninvasive methods to detect liver steatosis, which can be a factor of liver fibrosis progression. This work aims to evaluate a novel ultrasonic controlled attenuation parameter (CAP) devised to target, specifically, liver steatosis using a sophisticated process based on vibration control transient elastography (VCTE™). CAP was first validated as an estimate of ultrasonic attenuation at 3.5 MHz using Field II simulations and tissue-mimicking phantoms. Performance of the CAP was then appraised on 115 patients, taking the histological grade of steatosis as reference. CAP was significantly correlated to steatosis (Spearman ρ = 0.81, p < 10(-16)). Area under receiver operative characteristic (ROC) curve (AUC) was equal to 0.91 and 0.95 for the detection of more than 10% and 33% of steatosis, respectively. Furthermore, results show that CAP can efficiently separate several steatosis grades. These promising results suggest that CAP is a noninvasive, immediate, objective and efficient method to detect and quantify steatosis.
Authors:
Magali Sasso; Michel Beaugrand; Victor de Ledinghen; Catherine Douvin; Patrick Marcellin; Raoul Poupon; Laurent Sandrin; Véronique Miette
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Publication Detail:
Type:  Journal Article     Date:  2010-09-27
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  36     ISSN:  1879-291X     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1825-35     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
Affiliation:
R&D Department, Echosens, Paris, France. magali.sasso@echosens.com
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