Document Detail

Control of vertebrate retinal cell production.
MedLine Citation:
PMID:  1728575     Owner:  NLM     Status:  MEDLINE    
Regeneration of vertebrate sensory cells can be seen as an extension and elaboration of the process of cellular repair and to understand repair requires knowledge of how cell division and cell fate are determined. To approach these problems, we have developed a slice culture for the teleost retina. Cells continue to divide in the same pattern in this slice culture as they do in vivo as demonstrated with [3H]thymidine labeling. Moreover, cells which divided in culture became retinal cell phenotypes as identified with monoclonal antibodies. Some presumptive rod progenitors in the outer nuclear layer in the center of the retina were also labeled cone-specific, possibly as a regeneration response. These data add to the evidence that cell fate is determined by the environment. This slice preparation will be a useful model system for analyzing putative environmental cues responsible for guiding cell proliferation and differentiation in the fish retina.
A F Mack; R D Fernald
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental neurology     Volume:  115     ISSN:  0014-4886     ISO Abbreviation:  Exp. Neurol.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-02-03     Completed Date:  1992-02-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  65-8     Citation Subset:  IM    
Institute of Neuroscience, University of Oregon, Eugene 97403.
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MeSH Terms
Cell Division
Organ Culture Techniques
Retina / cytology*
Retinal Ganglion Cells / cytology*
Species Specificity
Thymidine / metabolism
Grant Support
Reg. No./Substance:
10028-17-8/Tritium; 50-89-5/Thymidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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