Document Detail

Control of ventilation in humans following intermittent hypoxia.
MedLine Citation:
PMID:  18461114     Owner:  NLM     Status:  MEDLINE    
Exposure to chronic or intermittent hypoxia produces alterations in the ventilatory response to hypoxia. These adaptations can differ depending on the severity of the hypoxic stimulus, its duration, its pattern, and the presence or absence of other chemical stimuli. As such, there are significant differences between the responses to intermittent versus continuous hypoxia. Intermittent hypoxia (IH) has been shown to elicit significant changes in the peripheral chemoresponse, but the functional implications of these changes for resting and exercise ventilation are not clear. We summarize the impact of IH on resting chemosensitivity and discuss the use of IH to better understand ventilatory control during exercise. We also suggest future directions for this relatively young field, including potential clinical applications of IH research.
Andrew William Sheel; Meaghan Joelle Macnutt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme     Volume:  33     ISSN:  1715-5312     ISO Abbreviation:  -     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-07     Completed Date:  2008-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  573-81     Citation Subset:  IM    
Health and Integrative Physiology Laboratory, School of Human Kinetics, University of British Columbia, Vancouver, BC V6T1Z3, Canada.
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MeSH Terms
Adaptation, Physiological / physiology*
Anoxia / physiopathology*
Exercise / physiology*
Pulmonary Ventilation / physiology*

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