Document Detail

Control of vascular responsiveness during human pregnancy.
MedLine Citation:
PMID:  6255223     Owner:  NLM     Status:  MEDLINE    
Normal human pregnancy is characterized by vascular refractoriness to AII. This pregnancy-induced vascular refractoriness appears to be mediated principally by decreased vascular smooth muscle responsiveness to AII rather than by alterations in blood volume or plasma concentrations of renin or AII. The mechanism that controls vascular refractoriness during normal pregnancy likely involves a localized prostaglandin or prostaglandin-like action mediated through cyclic nucleotides. The action of progesterone or one of its metabolites appears to mediate the synthesis or the catabolism of locally produced prostaglandins or prostaglandin-like agents.
N F Gant; R J Worley; R B Everett; P C MacDonald
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Kidney international     Volume:  18     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1980 Aug 
Date Detail:
Created Date:  1981-02-19     Completed Date:  1981-02-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  253-8     Citation Subset:  IM    
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MeSH Terms
20-alpha-Dihydroprogesterone / pharmacology
Angiotensin II / administration & dosage,  pharmacology*
Aspirin / pharmacology
Blood Vessels / drug effects*
Cyclic AMP / physiology
Hypertension / etiology,  physiopathology
Indomethacin / pharmacology
Muscle, Smooth, Vascular / drug effects
Pregnancy Complications, Cardiovascular / physiopathology
Progesterone / pharmacology
Prostaglandins / metabolism,  physiology
Theophylline / pharmacology
Grant Support
Reg. No./Substance:
0/Prostaglandins; 11128-99-7/Angiotensin II; 145-14-2/20-alpha-Dihydroprogesterone; 50-78-2/Aspirin; 53-86-1/Indomethacin; 57-83-0/Progesterone; 58-55-9/Theophylline; 60-92-4/Cyclic AMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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