Document Detail

Control of systemic and pulmonary blood pressure by nitric oxide formed through neuronal nitric oxide synthase.
MedLine Citation:
PMID:  19587610     Owner:  NLM     Status:  MEDLINE    
Nitric oxide formed by neuronal nitric oxide synthase (nNOS) in the brain, autonomic inhibitory (nitrergic) nerves, and heart plays important roles in the control of blood pressure. Activation of nitrergic nerves innervating the systemic vasculature elicits vasodilatation, decreases peripheral resistance, and lowers blood pressure. Impairment of nitrergic nerve function, as well as endothelial dysfunction, results in systemic and pulmonary hypertension and decreased regional blood flow. Blockade of nNOS activity in the brain, particularly the medulla and hypothalamus, causes systemic hypertension. Under hypertensive states, such as those in spontaneously hypertensive and Dahl salt-sensitive rats, the expression of the nNOS gene in the brain is increased; this appears to counteract the activated sympathetic function in the vasomotor center. The present article summarizes information concerning the modulation of systemic and pulmonary hypertension through nNOS-derived nitric oxide produced in the brain and periphery.
Noboru Toda; Kazuhide Ayajiki; Tomio Okamura
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of hypertension     Volume:  27     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-11-09     Completed Date:  2010-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1929-40     Citation Subset:  IM    
Department of Pharmacology, Shiga University of Medical Science, Otsu, Japan.
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MeSH Terms
Blood Pressure / physiology*
Hypertension / metabolism*,  physiopathology
Hypertension, Pulmonary / metabolism*,  physiopathology
Nitric Oxide / metabolism*
Nitric Oxide Synthase Type I / metabolism*
Reg. No./Substance:
10102-43-9/Nitric Oxide; EC Oxide Synthase Type I

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