Document Detail


Control of sensorimotor function by dopaminergic nigrostriatal neurons: influence on eating and drinking.
MedLine Citation:
PMID:  3010199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The literature on the effects of lesions of the lateral hypothalamic area (LHA) on eating and drinking is reviewed in an effort to understand the function of the neural substrate destroyed. The data suggest that damage to the dopaminergic nigrostriatal neurons that course through the LHA results in a decrease in sensorimotor facilitation; that is, an increase in the threshold for responding to stimuli that elicit orientation, approach and consumption. This increase results in decreased consumption of food and water. Evidence is also reviewed suggesting the possibility that striatal dopaminergic activity may mediate a negative feedback signal related to blood glucose level that influences responsiveness to food, and therefore eating. There is no evidence that the nigrostriatal system mediates a similar signal related to water balance and drinking. A second deficit associated with LHA lesions, caused by damage to the pallidofugal neurons that descend through this area, is a dysfunction of motor control of the head and mouth. This results in an increase in the effort required to consume food and water, also leading to decreased consumption. These two behavioral factors: an increased threshold for responding to the sensory properties of food and water and an increase in the effort required to eat and drink are used to explain the symptoms making up the lateral hypothalamic syndrome without postulating changes in physiological regulatory (set point) mechanisms.
Authors:
N M White
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Neuroscience and biobehavioral reviews     Volume:  10     ISSN:  0149-7634     ISO Abbreviation:  Neurosci Biobehav Rev     Publication Date:  1986  
Date Detail:
Created Date:  1986-06-09     Completed Date:  1986-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806090     Medline TA:  Neurosci Biobehav Rev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  15-36     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / physiology
Body Weight
Brain Mapping
Corpus Striatum / physiology*
Dopamine / physiology*
Drinking Behavior / physiology*
Electric Stimulation
Feedback
Feeding Behavior / physiology*
Homeostasis
Hydroxydopamines / pharmacology
Hypothalamic Area, Lateral / physiology
Insulin / pharmacology
Male
Motor Activity / physiology
Neural Pathways / physiology
Oxidopamine
Rats
Receptors, Dopamine / physiology
Satiety Response / physiology
Sensation / physiology
Substantia Nigra / physiology*
Synaptic Transmission
Taste / physiology
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hydroxydopamines; 0/Receptors, Dopamine; 11061-68-0/Insulin; 1199-18-4/Oxidopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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