Document Detail


Control of reproduction with anti-progestin and oestrogens in captive bears.
MedLine Citation:
PMID:  11787158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to establish new methods for controlling reproduction in bears. Anti-progestins were used to interrupt pregnancies. In two consecutive years, the anti-progestin J956 was administered to 11 female bears (nine Ursus arctos, one Ursus tibethanus, one Tremarctos ornatus) living in zoos. The anti-progestin J956 was given orally (n = 4) or parenterally (n = 12). The anti-progestin was administered alone or in combination with ethinyloestradiol, and before or after embryo implantation. The effects of anti-progestin treatment were determined using ultrasonographic examination of the urogenital tract and by monitoring progesterone concentrations in the blood and faeces. Oral administration of anti-progestin was not successful (successful in 0 of 4); however, in contrast, none of the parenteral treated animals remained pregnant (successful in 12 of 12). Parenteral treatment with J956, with or without ethinyloestradiol, was effective in disrupting pregnancy before implantation (successful in 6 of 6) and after implantation (successful in 6 of 6), but administration one month after implantation (n = 2) resulted in incomplete resorption of the fetuses. In conclusion, the administration of anti-progestins may be a useful method for preventing embryo implantation in captive bears.
Authors:
F Göritz; M Quest; T Hildebrandt; H H Meyer; L Kolter; W Elger; K Jewgenow
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of reproduction and fertility. Supplement     Volume:  57     ISSN:  0449-3087     ISO Abbreviation:  J. Reprod. Fertil. Suppl.     Publication Date:  2001  
Date Detail:
Created Date:  2002-01-11     Completed Date:  2002-02-19     Revised Date:  2012-03-02    
Medline Journal Info:
Nlm Unique ID:  0225652     Medline TA:  J Reprod Fertil Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  249-54     Citation Subset:  IM    
Affiliation:
Institute for Zoo Biology and Wildlife Research, PF 601103, D-10252 Berlin, Germany.
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MeSH Terms
Descriptor/Qualifier:
Abortifacient Agents / administration & dosage*
Abortion, Induced / veterinary*
Abortion, Veterinary*
Administration, Oral
Animals
Animals, Zoo*
Embryo Implantation / drug effects
Embryo Implantation, Delayed / drug effects
Estrenes
Ethinyl Estradiol / administration & dosage
Female
Infusions, Parenteral
Oximes / administration & dosage*
Oxytocics / administration & dosage*
Pregnancy
Progesterone / antagonists & inhibitors*
Ultrasonography, Prenatal / veterinary
Ursidae*
Chemical
Reg. No./Substance:
0/4-(17beta-methoxy-17alpha-(methoymethyl)-3-oxoestra-4,9-dien-11beta-yl)benzaldehyd-1-(E)-(O-(ethylamino)carbonyl)oxime; 0/Abortifacient Agents; 0/Estrenes; 0/Oximes; 0/Oxytocics; 57-63-6/Ethinyl Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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