Document Detail

Control of pulmonary vascular tone during exercise in health and pulmonary hypertension.
MedLine Citation:
PMID:  18586325     Owner:  NLM     Status:  MEDLINE    
Despite the importance of the pulmonary circulation as a determinant of exercise capacity in health and disease, studies into the regulation of pulmonary vascular tone in the healthy lung during exercise are scarce. This review describes the current knowledge of the role of various endogenous vasoactive mechanisms in the control of pulmonary vascular tone at rest and during exercise. Recent studies demonstrate an important role for endothelial factors (NO and endothelin) and neurohumoral factors (noradrenaline, acetylcholine). Moreover, there is evidence that natriuretic peptides, reactive oxygen species and phosphodiesterase activity can influence resting pulmonary vascular tone, but their role in the control of pulmonary vascular tone during exercise remains to be determined. K-channels are purported end-effectors in control of pulmonary vascular tone. However, K(ATP) channels do not contribute to regulation of pulmonary vascular tone, while the role of K(V) and K(Ca) channels at rest and during exercise remains to be determined. Pulmonary hypertension is associated with alterations in pulmonary vascular function and structure, resulting in blunted pulmonary vasodilatation during exercise and impaired exercise capacity. Although there is a paucity of studies pertaining to the regulation of pulmonary vascular tone during exercise in idiopathic pulmonary hypertension, the few studies that have been performed in models of pulmonary hypertension secondary to left ventricular dysfunction suggest altered control of pulmonary vascular tone during exercise. Since the increased pulmonary vascular tone during exercise limits exercise capacity, future studies are needed to investigate the vasomotor mechanisms that are responsible for the blunted exercise-induced pulmonary vasodilatation in pulmonary hypertension.
Daphne Merkus; Vincent J de Beer; Birgit Houweling; Dirk J Duncker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-05-14
Journal Detail:
Title:  Pharmacology & therapeutics     Volume:  119     ISSN:  0163-7258     ISO Abbreviation:  Pharmacol. Ther.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-08     Completed Date:  2009-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905840     Medline TA:  Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  242-63     Citation Subset:  IM    
Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus MC, University Medical Center Rotterdam, The Netherlands.
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MeSH Terms
Endothelium, Vascular / metabolism,  physiopathology
Exercise / physiology*
Hypertension, Pulmonary / metabolism,  physiopathology*
Models, Biological
Natriuretic Peptides / metabolism
Pulmonary Circulation / physiology*
Reactive Oxygen Species / metabolism
Vasoconstriction / physiology*
Reg. No./Substance:
0/Natriuretic Peptides; 0/Reactive Oxygen Species

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