Document Detail


Control of postganglionic sympathetic efferent fibers by neurokinin 1 receptors in rats.
MedLine Citation:
PMID:  14665415     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Substance P (SP) is released peripherally from nociceptive terminals and has a direct effect on vascular cells. The present study suggests an indirect effect as well. In normal rats and rats with one hindpaw inflamed for 48 h following intraplantar injection of complete Freund's adjuvant, neurokinin 1 (NK1) receptors were immunohistochemically localized on postganglionic sympathetic axons. The percentage of NK1-labeled axons in the gray rami from normal rats was 35.0+/-5.0; in inflamed rats this percentage increased significantly to 49.1+/-2.3. These data suggest a sensory-sympathetic reflex, where SP activates these peripheral sympathetic receptors with subsequent release of noradrenaline and other compounds to affect vascular cells indirectly. This control is enhanced after inflammation.
Authors:
Richard E Coggeshall; Susan M Carlton
Related Documents :
8321515 - Innervation of the ciliary process vasculature and epithelium by nerve fibers containin...
23118025 - Primocolonization is associated with colonic epithelial maturation during conventionali...
90065 - Superior sensitivity of conjugates of horseradish peroxidase with wheat germ agglutinin...
9383035 - Cellular retinaldehyde-binding protein is expressed by oligodendrocytes in optic nerve ...
17126515 - Protective effect of an extract of the oyster mushroom, pleurotus ostreatus, on antioxi...
12419325 - Expression of v-1, a novel catecholamine biosynthesis regulatory protein, is enhanced b...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  353     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-10     Completed Date:  2004-02-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  197-200     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, Galveston, TX 77555-1069, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Axons / metabolism
Cell Count
Freund's Adjuvant
Hindlimb / metabolism
Immunohistochemistry / methods
Inflammation / chemically induced,  metabolism
Male
Rats
Rats, Sprague-Dawley
Receptors, Neurokinin-1 / metabolism*
Sympathetic Fibers, Postganglionic / cytology,  metabolism*
Grant Support
ID/Acronym/Agency:
NS10161/NS/NINDS NIH HHS; NS11255/NS/NINDS NIH HHS; NS27910/NS/NINDS NIH HHS; NS40700/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Neurokinin-1; 9007-81-2/Freund's Adjuvant

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Sensitivity of human EEG alpha band desynchronization to different working memory components and inc...
Next Document:  Association between small apolipoprotein(a) isoforms and frontotemporal dementia in humans.