Document Detail

Control of perfusion pressure and flow in isolated heart bioassays.
MedLine Citation:
PMID:  3236865     Owner:  NLM     Status:  MEDLINE    
Bioassays using isolated animal hearts are important tools for the investigation of cardiac behaviour, but to obtain accurate results a proper perfusion circuit has to be designed. In particular, biophysical studies of contractile and vascular behaviour require a perfusion circuit which permits the adjustment of several experimental parameters within wide ranges. It must also be able to maintain the stability of these parameters when the behaviour of the isolated organ undergoes major changes. To meet this requirement, we have developed a perfusion circuit which makes it possible to control either the perfusion pressure or the coronary flow, with a high degree of precision. There is an electronic controller which satisfies the requirements of a variety of safety and experimental requirements and guarantees a well-defined perfusion system. Computer simulation of the interaction between the perfusion circuit and the heart identified the basic elements of this time-variable, nonlinear system.
H Schima; J Newald; P Krösl; M Thurnher; G Schlag
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of biomedical engineering     Volume:  10     ISSN:  0141-5425     ISO Abbreviation:  J Biomed Eng     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1989-05-04     Completed Date:  1989-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906074     Medline TA:  J Biomed Eng     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  387-92     Citation Subset:  IM    
Boltzmann Institute of Experimental Traumatology, Vienna, Austria.
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MeSH Terms
Computer Simulation
Equipment Design
Heart / physiology*
Perfusion / instrumentation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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