| Control of muscle protein breakdown: effects of activity and nutritional states. | |
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MedLine Citation:
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PMID: 11915916 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We propose that there is a link between muscle protein synthesis and breakdown that is regulated, in part, through maintenance of the free intracellular pool of essential amino acids. For example, we propose that muscle protein breakdown is paradoxically elevated in the anabolic state following resistance exercise in part because the even greater stimulation of synthesis would otherwise deplete this pool. Thus, factors regulating muscle protein breakdown must be evaluated in the context of the prevailing rate of muscle protein synthesis. Further, the direct effect of factors on breakdown may depend on the physiological state. For example, local hyperinsulinemia suppresses accelerated muscle protein breakdown after exercise, but not normal resting breakdown. Thus, factors regulating muscle protein breakdown in human subjects are complex and interactive. |
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Authors:
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R R Wolfe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: International journal of sport nutrition and exercise metabolism Volume: 11 Suppl ISSN: 1526-484X ISO Abbreviation: Int J Sport Nutr Exerc Metab Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2002-03-27 Completed Date: 2002-09-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100939812 Medline TA: Int J Sport Nutr Exerc Metab Country: United States |
Other Details:
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Languages: eng Pagination: S164-9 Citation Subset: IM; S |
Affiliation:
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Department of Surgery/Metabolism, University of Texas Medical Branch, Shriners Burns Hospital, Galveston 77550, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids, Essential
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administration & dosage,
metabolism* Bed Rest / adverse effects Burns / metabolism Energy Metabolism / physiology* Exercise / physiology Humans Hydrocortisone / administration & dosage, blood Insulin / blood Muscle Proteins / biosynthesis, metabolism* Muscle, Skeletal / metabolism* Muscular Atrophy / metabolism* Nutritional Status Weight Lifting / physiology |
| Grant Support | |
ID/Acronym/Agency:
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AG15780/AG/NIA NIH HHS; AG17231/AG/NIA NIH HHS; DK38010/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids, Essential; 0/Muscle Proteins; 11061-68-0/Insulin; 50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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