| Control of muscle blood flow during exercise: local factors and integrative mechanisms. | |
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MedLine Citation:
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PMID: 20353492 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Understanding the control mechanisms of blood flow within the vasculature of skeletal muscle is clearly fascinating from a theoretical point of view due to the extremely tight coupling of tissue oxygen demands and blood flow. It also has practical implications as impairment of muscle blood flow and its prevention/reversal by exercise training has a major impact on widespread diseases such as hypertension and diabetes. Here we analyse the role of mediators generated by skeletal muscle activity on smooth muscle relaxation in resistance vessels in vitro and in vivo. We summarize their cellular mechanisms of action and their relative roles in exercise hyperaemia with regard to early and late responses. We also discuss the consequences of interactions among mediators with regard to identifying their functional significance. We focus on (potential) mechanisms integrating the action of the mediators and their effects among the cells of the intact arteriolar wall. This integration occurs both locally, partly due to myoendothelial communication, and axially along the vascular tree, thus enabling the local responses to be manifest along an entire functional vessel path. Though the concept of signal integration is intriguing, its specific role on the control of exercise hyperaemia and the consequences of its modulation under physiological and pathophysiological conditions still await additional analysis. |
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Authors:
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I Sarelius; U Pohl |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-03-26 |
Journal Detail:
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Title: Acta physiologica (Oxford, England) Volume: 199 ISSN: 1748-1716 ISO Abbreviation: Acta Physiol (Oxf) Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-10-25 Revised Date: 2011-08-25 |
Medline Journal Info:
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Nlm Unique ID: 101262545 Medline TA: Acta Physiol (Oxf) Country: England |
Other Details:
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Languages: eng Pagination: 349-65 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Physiology, University of Rochester, Rochester, New York, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterioles / cytology, metabolism Exercise / physiology* Hemodynamics Humans Muscle, Skeletal / blood supply*, physiology Muscle, Smooth, Vascular / physiology Nitric Oxide / metabolism Oxygen / metabolism Regional Blood Flow / physiology* Vasoconstriction / physiology Vasodilation / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL 76414/HL/NHLBI NIH HHS; R01 HL076414-04/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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