Document Detail


Control in time and space: Tramtrack69 cooperates with Notch and Ecdysone to repress ectopic fate and shape changes during Drosophila egg chamber maturation.
MedLine Citation:
PMID:  19934014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Organ morphogenesis requires cooperation between cells, which determine their course of action based upon location within a tissue. Just as important, cells must synchronize their activities, which requires awareness of developmental time. To understand how cells coordinate behaviors in time and space, we analyzed Drosophila egg chamber development. We found that the transcription factor Tramtrack69 (TTK69) controls the fates and shapes of all columnar follicle cells by integrating temporal and spatial information, restricting characteristic changes in morphology and expression that occur at stage 10B to appropriate domains. TTK69 is required again later in oogenesis: it controls the volume of the dorsal-appendage (DA) tubes by promoting apical re-expansion and lateral shortening of DA-forming follicle cells. We show that TTK69 and Notch compete to repress each other's expression and that a local Ecdysone signal is required to shift the balance in favor of TTK69. We hypothesize that TTK69 then cooperates with spatially restricted co-factors to define appropriate responses to a globally available (but as yet unidentified) temporal signal that initiates the S10B transformations.
Authors:
Michael J Boyle; Celeste A Berg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  136     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-02-09     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  4187-97     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation
Drosophila / physiology*
Drosophila Proteins / physiology*
Ecdysone / metabolism
Female
Gene Expression Regulation
Oogenesis / physiology*
Ovarian Follicle / cytology,  physiology
Receptors, Notch / physiology*
Repressor Proteins / physiology*
Signal Transduction
Grant Support
ID/Acronym/Agency:
R01 GM079433/GM/NIGMS NIH HHS; R01-GM079433/GM/NIGMS NIH HHS; T32 HD007183/HD/NICHD NIH HHS; T32 HD007183/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/Receptors, Notch; 0/Repressor Proteins; 0/notch protein, Drosophila; 0/ttk protein, Drosophila; 3604-87-3/Ecdysone
Comments/Corrections

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