| Control of immune response by amino acid metabolism. | |
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MedLine Citation:
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PMID: 20636821 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The interaction between pathogenic microorganisms and their hosts is regulated by reciprocal survival strategies, including competition for essential nutrients. Though paradoxical, mammalian hosts have learned to take advantage of amino acid catabolism for controlling pathogen invasion and, at the same time, regulating their own immune responses. In this way, ancient catabolic enzymes have acquired novel functions and evolved into new structures with highly specialized functions, which go beyond the struggle for survival. In this review, we analyze the evidence supporting a critical role for the metabolism of various amino acids in regulating different steps of both innate and adaptive immunity. |
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Authors:
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Ursula Grohmann; Vincenzo Bronte |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Immunological reviews Volume: 236 ISSN: 1600-065X ISO Abbreviation: Immunol. Rev. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7702118 Medline TA: Immunol Rev Country: Denmark |
Other Details:
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Languages: eng Pagination: 243-64 Citation Subset: IM |
Affiliation:
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Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptive Immunity
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immunology* Amino Acids / metabolism* Animals Cell Survival / immunology Humans Immunity, Innate / immunology* Indoleamine-Pyrrole 2,3,-Dioxygenase / classification, genetics, metabolism Lymphocytes / cytology, immunology, metabolism Phylogeny Tryptophan / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 73-22-3/Tryptophan; EC 1.13.11.42/Indoleamine-Pyrrole 2,3,-Dioxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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