Document Detail

Control of immune response by amino acid metabolism.
MedLine Citation:
PMID:  20636821     Owner:  NLM     Status:  MEDLINE    
The interaction between pathogenic microorganisms and their hosts is regulated by reciprocal survival strategies, including competition for essential nutrients. Though paradoxical, mammalian hosts have learned to take advantage of amino acid catabolism for controlling pathogen invasion and, at the same time, regulating their own immune responses. In this way, ancient catabolic enzymes have acquired novel functions and evolved into new structures with highly specialized functions, which go beyond the struggle for survival. In this review, we analyze the evidence supporting a critical role for the metabolism of various amino acids in regulating different steps of both innate and adaptive immunity.
Ursula Grohmann; Vincenzo Bronte
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  236     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  243-64     Citation Subset:  IM    
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy.
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MeSH Terms
Adaptive Immunity / immunology*
Amino Acids / metabolism*
Cell Survival / immunology
Immunity, Innate / immunology*
Indoleamine-Pyrrole 2,3,-Dioxygenase / classification,  genetics,  metabolism
Lymphocytes / cytology,  immunology,  metabolism
Tryptophan / metabolism
Reg. No./Substance:
0/Amino Acids; 73-22-3/Tryptophan; EC 2,3,-Dioxygenase

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