| Control of homologous chromosome division in the mammalian oocyte. | |
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MedLine Citation:
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PMID: 19179408 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Homologous chromosomes are segregated during the first meiotic division (meiosis I). Unfortunately, human oocytes are particularly susceptible to mis-segregation errors, so generating aneuploid, often non-viable, embryos. Here we review the cell biology of meiosis I and how homolog disjunction is regulated for mammalian oocytes. We focus on the activity of the anaphase-promoting complex/cyclosome (APC/C), which is responsible for timely degradation of the cohesin component, REC8 and the cyclin B regulatory subunit of maturation-promoting factor, both essential steps for meiosis I completion. In particular, we examine the role played by the spindle assembly checkpoint in controlling the APC/C activity, and in so doing ensuring accurate disjunction of homologs. |
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Authors:
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Janet E Holt; Keith T Jones |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-01-29 |
Journal Detail:
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Title: Molecular human reproduction Volume: 15 ISSN: 1460-2407 ISO Abbreviation: Mol. Hum. Reprod. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-02-25 Completed Date: 2009-05-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9513710 Medline TA: Mol Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 139-47 Citation Subset: IM |
Affiliation:
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University of Newcastle, Callaghan, NSW, Australia. Janet.Holt@newcastle.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aneuploidy Animals Chromosome Segregation / genetics* Female Humans Meiosis / genetics Models, Biological Oocytes / metabolism* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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