Document Detail

Control of heparinization by activated clotting time during bypass with improved postoperative hemostasis.
MedLine Citation:
PMID:  879898     Owner:  NLM     Status:  MEDLINE    
Heparin and protamine dosages monitored during open-heart operations by activated clotting time (ACT) have been reported to be superior to dosage schedules based on body weight or body surface area. To evaluate the automated ACT, 114 consecutive open-heart operations performed between October, 1974, and December, 1975, were studied. Fifty-eight operations prior to April, 1975, using a standard heparin-protamine protocol (Group I) were compared with 56 operations from April to December, 1975, monitored with an automated ACT (Group II). The two groups were similar with respect to surgical procedures, pump time, and perfusion techniques. The protamine/heparin ratio was 25% less in Group II compared with Group I, and the 12-hour postoperative blood loss was 48% less in Group II. The automated ACT is a reliable, rapid, and simple test that has resulted in improved hemostasis following cardiac operation.
J J Verska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  24     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-09-02     Completed Date:  1977-09-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  170-3     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Coagulation Tests
Cardiopulmonary Bypass*
Hemostasis, Surgical*
Heparin / administration & dosage*
Protamines / administration & dosage
Reg. No./Substance:
0/Protamines; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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