Document Detail


Control of the heart in the mudpuppy, Necturus maculosus.
MedLine Citation:
PMID:  4085609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cardiac innervation of the mudpuppy, Necturus maculosus, was investigated using in vivo recording of blood pressure and heart rate, a perfused heart preparation, isolated paced ventricular and atrial strip preparations, Falck-Hillarp fluorescence histochemistry and measurements of plasma concentrations of catecholamines. The heart of Necturus receives a 'classical' vagal inhibitory innervation by cholinergic fibres which act via muscarinic cholinoceptors. In addition, there appears to be an atropine-resistant inhibitory component in the vagal innervation of the heart. This component is best seen at higher frequencies of vagal stimulation (10-20 Hz), but the mechanism behind this response is not known. There is no direct adrenergic innervation of the ventricle or atria, but by use of Falck-Hillarp fluorescence histochemistry, adrenergic fibres have been demonstrated at the atrio-ventricular border, particularly within the intracardiac ganglion. The histochemical evidence is consistent with a modulation of the ganglionic transmission in the vagal pathways by adrenergic neurons and small intensely fluorescent (SIF) cells, but physiological evidence is wanting. An adrenergic control of the heart via circulating adrenaline may occur during 'stress', when the plasma level of adrenaline is high enough to affect cardiac performance.
Authors:
M Axelsson; S Nilsson
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental biology     Volume:  44     ISSN:  0176-8638     ISO Abbreviation:  Exp Biol     Publication Date:  1985  
Date Detail:
Created Date:  1986-03-26     Completed Date:  1986-03-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8503247     Medline TA:  Exp Biol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  229-39     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Animals
Atrial Function
Atropine / pharmacology
Blood Pressure / drug effects
Catecholamines / blood
Electric Stimulation
Epinephrine / pharmacology
Heart / physiology*
Heart Conduction System*
Heart Rate / drug effects
Microscopy, Fluorescence
Necturus / physiology*
Perfusion
Vagus Nerve / physiology
Ventricular Function
Chemical
Reg. No./Substance:
0/Catecholamines; 51-43-4/Epinephrine; 51-55-8/Atropine; 51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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