Document Detail


Control of glycogen metabolism by gluconeogenic and ketogenic substrates in isolated hepatocytes from fed rats.
MedLine Citation:
PMID:  1582529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. This study was conducted to examine the effects of gluconeogenic and ketogenic substrates on the activities of the glycogen-metabolizing enzymes and on glycogenolysis in isolated hepatocytes from fed rats. 2. Gluconeogenic substrates like fructose, dihydroxyacetone or lactate turned out to stimulate the glucose-induced activation of glycogen synthase and this effect may be linked, to some extent, to the increase of the cellular glucose 6-phosphate concentration. 3. The effect of fructose was accompanied by the onset of glycogen synthesis. 4. Energetic substrates like fatty acids were also potent activators of glycogen synthase, especially in the presence of glucose. 5. When fatty acids were added alone or together with a physiological concentration of glucose, they induced or potentiated the inhibition of glycogen phosphorylase-a. 6. This inhibitory effect was mediated by a decrease of lactate release. 7. The stimulatory effect of amino acids on glycogen synthase seemed to be direct, non mediated by an inhibition of the phosphorylase-a activity although hepatic glycogenolysis markedly decreased. 8. Moreover, the amino acid action could be linked to their capacities to induce cell swelling and/or to limit proteolysis.
Authors:
C Morand; C Remesy; C Besson; C Demigne
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of biochemistry     Volume:  24     ISSN:  0020-711X     ISO Abbreviation:  Int. J. Biochem.     Publication Date:  1992  
Date Detail:
Created Date:  1992-06-16     Completed Date:  1992-06-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0250365     Medline TA:  Int J Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  159-67     Citation Subset:  IM    
Affiliation:
Laboratoires des Maladies Métaboliques, I.N.R.A. Theix, Ceyrat, France.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism
Animals
Fatty Acids / metabolism
Gluconeogenesis*
Glucose / metabolism
Glycogen / metabolism*
Glycogen Synthase / metabolism
Liver / enzymology,  metabolism*
Male
Phosphorylase a / metabolism
Rats
Rats, Inbred Strains
Substrate Specificity
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Fatty Acids; 50-99-7/Glucose; 9005-79-2/Glycogen; EC 2.4.1.-/Phosphorylase a; EC 2.4.1.11/Glycogen Synthase

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