Document Detail

Control of food intake by MC4-R signaling in the lateral hypothalamus, nucleus accumbens shell and ventral tegmental area: interactions with ethanol.
MedLine Citation:
PMID:  22713514     Owner:  NLM     Status:  MEDLINE    
The melanocortin system is involved in animal models of obesity and anorexia-cachexia and MC4 receptors (MC4-R) are currently a target system for the development of drugs aimed to treat obesity and eating disorders in humans. Previous evidence suggest that feeding peptides might lack their orexigenic activity while stimulate ethanol intake. The present study comparatively evaluated food intake (4-h interval) in Sprague-Dawley (SD) rats drinking ethanol (6% w/v, 2 bottle choice paradigm) (EE group) and ethanol-naïve (EN) rats in response to bilateral infusion of the selective MC4-R antagonist HS014 (0, 0.02 or 0.05 μg/0.5 μl/site) or the selective MC4-R agonist cyclo(NH-CH(2)-CH(2)-CO-His-d-Phe-Arg-Trp-Glu)-NH(2) (0, 0.75 or 1.5 μg/0.5 μl/site), into the lateral hypothalamus (LH), the nucleus accumbens (NAc), or the ventral tegmental area (VTA). The main findings in the study are: (1) LH-infusions of the MC4-R antagonist increased and the agonist reduced feeding and total calories consumed, while ethanol intake remained unaltered. (2) NAc- and VTA-infusions of the selective agonist reduced food, ethanol and total calories intake. (3) NAc- and VTA-infusions of the MC4-R antagonist increased feeding in EN rats, but not in EE animals which showed a mild increase in ethanol intake, while total calories consumed remained unaltered. Present data show that having ethanol available reduces feeding elicited by NAc and VTA-MC4-R blockade. Additionally, while MC4-R signaling in the LH appears to modulate homeostatic aspects of feeding, it may contribute to non-homeostatic aspects of ingestive behaviors in the VTA and the NAc.
Jose M Lerma-Cabrera; Francisca Carvajal; Lourdes de la Torre; Leticia de la Fuente; Montserrat Navarro; Todd E Thiele; Inmaculada Cubero
Related Documents :
19762664 - Improving patrons' meal selections through the use of point-of-selection nutrition labels.
22713514 - Control of food intake by mc4-r signaling in the lateral hypothalamus, nucleus accumben...
15209444 - Consumer protection from an eu regulation on the mandatory labelling of genetically mod...
19500624 - Medicalisation of food advertising. nutrition and health claims in magazine food advert...
17720204 - A thermodynamic perspective on food webs: quantifying entropy production within detrita...
25049134 - Initial evidence that glp-1 receptor blockade fails to suppress postprandial satiety or...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-06-17
Journal Detail:
Title:  Behavioural brain research     Volume:  234     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-07-30     Completed Date:  2012-12-07     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  51-60     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Departamento de Neurociencia y Ciencias de Salud, Universidad de Almería, Almería, 04120, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain / drug effects*,  metabolism
Eating / drug effects*
Ethanol / pharmacology*
Feeding Behavior / drug effects*
Hypothalamus / drug effects,  metabolism
Nucleus Accumbens / drug effects,  metabolism
Rats, Sprague-Dawley
Receptor, Melanocortin, Type 4 / agonists,  antagonists & inhibitors,  metabolism
Signal Transduction / drug effects*
Ventral Tegmental Area / drug effects,  metabolism
Grant Support
Reg. No./Substance:
0/Receptor, Melanocortin, Type 4; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The clinical diagnostic significance of cerebrospinal fluid D-Lactate for bacterial meningitis.
Next Document:  Lactation and cardiovascular risk factors in mothers in a population-based study: the HUNT-study.