Document Detail


Control of fetal breathing in the human fetus between 24 and 34 weeks' gestation.
MedLine Citation:
PMID:  2496603     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of induced maternal hypocapnia and hypercapnia on fetal breathing movements was studied in 30 healthy pregnant women between 24 and 34 weeks' gestation to determine whether gestational age influences the fetal respiratory response to alterations in carbon dioxide levels. The percent time of fetal breathing movements correlated significantly with maternal end-tidal PCO2, increasing with maternal breathing of 2% and 4% carbon dioxide and decreasing with maternal hyperventilation for each of the three gestational age groups studied. However, the slope of this response for the 28- to 30-week group (3.29) and for the 32- to 34-week group (3.66), although similar to that of the term fetus, was significantly greater than that for the 24- to 26-week group (1.18, p less than 0.001). We conclude that the carbon dioxide level in the preterm fetus (as in the term fetus) is an important stimulus for the generation of respiratory movements. However, a developmental change is evident; the 24- to 26-week fetus demonstrates a decreased respiratory response to tonic carbon dioxide input. This may account for the decreased incidence of fetal breathing movements in the fetus of younger gestational age.
Authors:
G Connors; C Hunse; L Carmichael; R Natale; B Richardson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  160     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-05-31     Completed Date:  1989-05-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  932-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynaecology, St. Joseph's Health Centre, London, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Carbon Dioxide / pharmacology
Female
Fetal Movement / drug effects
Fetus / physiology*
Gestational Age
Heart Rate, Fetal / drug effects
Humans
Pregnancy
Respiration / drug effects
Respiratory Physiological Phenomena*
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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