Document Detail


Control of fatty acid and glycerol release in adipose tissue lipolysis.
MedLine Citation:
PMID:  16860278     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adipose tissue lipolysis is the catabolic process leading to the breakdown of triglycerides stored in fat cells and the release of fatty acids and glycerol. Recent work has revealed that lipolysis is not a simple metabolic pathway stimulated by catecholamines and inhibited by insulin. New discoveries on the regulation of lipolysis by endocrine and paracrine factors and on the proteins involved in triglyceride hydrolysis have led to a reappraisal of the complexity of the various signal transduction pathways. The steps involved in the dysregulation of lipolysis observed in obesity have partly been identified.
Authors:
Dominique Langin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-04-27
Journal Detail:
Title:  Comptes rendus biologies     Volume:  329     ISSN:  1631-0691     ISO Abbreviation:  C. R. Biol.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-24     Completed Date:  2006-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101140040     Medline TA:  C R Biol     Country:  France    
Other Details:
Languages:  eng     Pagination:  598-607; discussion 653-5     Citation Subset:  IM    
Affiliation:
Unité de recherches sur les obésités, INSERM UPS U586, institut Louis-Bugnard, université Paul-Sabatier, CHU Rangueil, BP 84225, 31432 Toulouse cedex 4, France. langin@toulouse.inserm.fr
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / physiology*
Animals
Fatty Acids / metabolism*
Glycerol / metabolism*
Humans
Hypoglycemic Agents
Lipolysis*
Triglycerides / metabolism
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Hypoglycemic Agents; 0/Triglycerides; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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