Document Detail

Control of emergence hypertension after craniotomy for brain tumor surgery.
MedLine Citation:
PMID:  21048604     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: To compare the anti-hypertensive effects of both remifentanil and esmolol infusion.
METHODS: This prospective comparative study was conducted on 20 patients (10 patients in each group), in the Neurosurgical Theater of Kasr Elaini Hospital, Cairo, Egypt from 2006 to 2008. The patients were divided into 2 equal groups. In group one, remifentanil was used as a bolus of one ug/kg intravenous (iv) in 30-60 seconds, followed by infusion at a rate of 0.25-0.5 ug/kg/min until the systolic blood pressure was <140 mm Hg. In group 2, esmolol was given as a 500 ug/kg iv bolus in 30 seconds followed by continued infusion of 100-300 ug/kg/min until systolic blood pressure was <140 mm Hg. Infusion was continued until the patients left the post anesthesia care unit (PACU).
RESULTS: The onset time of decreasing blood pressure was shorter in group 2 (40+/-0.01 seconds) than group one (52.5+/-4.47 seconds). The PACU and hospital stay were comparable between both groups.
CONCLUSION: Remifentanil can be used to control blood pressure during emergence of anesthesia after craniotomy for brain tumors. It has higher rapid recovery score than esmolol and other narcotics. In addition, it can be used when esmolol is contraindicated such as in cardiac patients, asthmatics, chronic obstructive pulmonary disease, or during pregnancy. Also, it decreases the need for postoperative analgesia and allows sedation if the infusion is continued as surgical patients are admitted to the ICU.
Hala M Goma; Mostafa Z Ali
Related Documents :
8571194 - Effects of differing rates of protamine reversal of heparin anticoagulation.
3549174 - Decreasing hydrostatic pressure does not uniformly decrease high-pressure pulmonary edema.
8957974 - Gut mucosal perfusion in neonates undergoing cardiopulmonary bypass.
15931474 - Modified extraperitoneal endoscopic separation of parts for abdominal compartment syndr...
12872054 - Cardiac effects of amiloride and of enalapril in the spontaneously hypertensive rat.
23130664 - Duration until nighttime blood pressure fall indicates excess sodium retention.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurosciences (Riyadh, Saudi Arabia)     Volume:  14     ISSN:  1319-6138     ISO Abbreviation:  Neurosciences (Riyadh)     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2010-11-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101252453     Medline TA:  Neurosciences (Riyadh)     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  167-71     Citation Subset:  -    
Department of Anesthesia, Faculty of Medicine, Cairo University, Cairo, Egypt. Tel. +20 (1) 22819043 /237796155. E-mail:
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Prevalence of neuropathy in the diabetic foot.
Next Document:  Ventriculo-sagittal sinus shunt malfunction. Causes of failure, avoidance, and alternatives.