Document Detail

Control of early embryonic heart morphogenesis: a hypothesis.
MedLine Citation:
PMID:  6557899     Owner:  NLM     Status:  MEDLINE    
The early events of looping (rotation and bending) of the embryonic vertebrate heart are deformations. The deformative forces and their regulation are intrinsic to the heart. A model of cardiac morphogenesis is described in this paper. It is proposed that synthesis of extracellular matrix by the myocardium generates an internal pressure. This pressure acts as a deforming force on the myocardium which controls strain by regulating compliance. This model provides an explanation of cardiac morphogenesis at the biochemical and biomechanical levels.
F J Manasek
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Ciba Foundation symposium     Volume:  100     ISSN:  0300-5208     ISO Abbreviation:  Ciba Found. Symp.     Publication Date:  1983  
Date Detail:
Created Date:  1984-02-14     Completed Date:  1984-02-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0356636     Medline TA:  Ciba Found Symp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  4-19     Citation Subset:  IM    
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MeSH Terms
Heart / embryology*
Grant Support

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