| Control of early embryonic heart morphogenesis: a hypothesis. | |
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MedLine Citation:
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PMID: 6557899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The early events of looping (rotation and bending) of the embryonic vertebrate heart are deformations. The deformative forces and their regulation are intrinsic to the heart. A model of cardiac morphogenesis is described in this paper. It is proposed that synthesis of extracellular matrix by the myocardium generates an internal pressure. This pressure acts as a deforming force on the myocardium which controls strain by regulating compliance. This model provides an explanation of cardiac morphogenesis at the biochemical and biomechanical levels. |
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Authors:
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F J Manasek |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Ciba Foundation symposium Volume: 100 ISSN: 0300-5208 ISO Abbreviation: Ciba Found. Symp. Publication Date: 1983 |
Date Detail:
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Created Date: 1984-02-14 Completed Date: 1984-02-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0356636 Medline TA: Ciba Found Symp Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 4-19 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Heart / embryology* Morphogenesis Vertebrates |
| Grant Support | |
ID/Acronym/Agency:
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HL 13831/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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