| Control of completeness and immediate detection of bleeding by a single laser-Doppler flow probe during intravascular middle cerebral artery occlusion in rats. | |
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MedLine Citation:
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PMID: 12535766 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To detect the unintentional generation of subarachnoid hemorrhage (SAH) during thread occlusion of the middle cerebral artery (MCA) in rats, a single laser-Doppler flowmetry (LDF) probe was positioned over the ipsilateral cortex. Occlusion of the MCA resulted in an immediate drop of the LDF signal to 21.4+/-8.0% which was followed by a partial recovery to 31+/-11% in animals without SAH. In contrast, a sustained decrease to 7.4+/-5% (P<0.05 vs. non-SAH) occurred in animals with SAH. Thus, unintentional rupturing of the intracerebral carotid artery can easily and reliably be detected by single LDF monitoring immediately after MCA occlusion. |
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Authors:
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Johannes Woitzik; Lothar Schilling |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of neuroscience methods Volume: 122 ISSN: 0165-0270 ISO Abbreviation: J. Neurosci. Methods Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2003-01-21 Completed Date: 2003-03-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905558 Medline TA: J Neurosci Methods Country: Netherlands |
Other Details:
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Languages: eng Pagination: 75-8 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, University Hospital Mannheim, University of Heidelburg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. johannes.woitzik@nch.ma.uni-heidelberg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity Brain / blood supply, pathology Disease Models, Animal Hypoxia-Ischemia, Brain / etiology, pathology* Infarction, Middle Cerebral Artery / complications, pathology*, physiopathology* Laser-Doppler Flowmetry / instrumentation*, methods* Male Middle Cerebral Artery / physiopathology, surgery Rats Rats, Sprague-Dawley Reference Values Subarachnoid Hemorrhage / diagnosis*, etiology, physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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