Document Detail

Control of completeness and immediate detection of bleeding by a single laser-Doppler flow probe during intravascular middle cerebral artery occlusion in rats.
MedLine Citation:
PMID:  12535766     Owner:  NLM     Status:  MEDLINE    
To detect the unintentional generation of subarachnoid hemorrhage (SAH) during thread occlusion of the middle cerebral artery (MCA) in rats, a single laser-Doppler flowmetry (LDF) probe was positioned over the ipsilateral cortex. Occlusion of the MCA resulted in an immediate drop of the LDF signal to 21.4+/-8.0% which was followed by a partial recovery to 31+/-11% in animals without SAH. In contrast, a sustained decrease to 7.4+/-5% (P<0.05 vs. non-SAH) occurred in animals with SAH. Thus, unintentional rupturing of the intracerebral carotid artery can easily and reliably be detected by single LDF monitoring immediately after MCA occlusion.
Johannes Woitzik; Lothar Schilling
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of neuroscience methods     Volume:  122     ISSN:  0165-0270     ISO Abbreviation:  J. Neurosci. Methods     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-01-21     Completed Date:  2003-03-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905558     Medline TA:  J Neurosci Methods     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  75-8     Citation Subset:  IM    
Department of Neurosurgery, University Hospital Mannheim, University of Heidelburg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
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MeSH Terms
Blood Flow Velocity
Brain / blood supply,  pathology
Disease Models, Animal
Hypoxia-Ischemia, Brain / etiology,  pathology*
Infarction, Middle Cerebral Artery / complications,  pathology*,  physiopathology*
Laser-Doppler Flowmetry / instrumentation*,  methods*
Middle Cerebral Artery / physiopathology,  surgery
Rats, Sprague-Dawley
Reference Values
Subarachnoid Hemorrhage / diagnosis*,  etiology,  physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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