| Control of cerebral cortical blood flow by stimulation of basal forebrain cholinergic areas in mice. | |
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MedLine Citation:
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PMID: 21424590 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We examined whether activity of the nucleus basalis of Meynert (NBM) regulates regional cerebral cortical blood flow (rCBF) in mice, using laser speckle and laser Doppler flowmetry. In anesthetized mice, unilateral focal stimulation, either electrical or chemical, of the NBM increased rCBF of the ipsilateral cerebral cortex in the frontal, parietal and occipital lobes, independent of changes in systemic blood pressure. Most of vasodilative responses to low intensity stimuli (2 times threshold intensity: 2T) were abolished by atropine (a muscarinic cholinergic blocker), whereas responses to higher intensity stimuli (3T) were abolished by atropine and mecamylamine (a nicotinic cholinergic blocker). Blood flow changes were largest when the tip of the electrode was located within the area containing cholinergic neurons shown by choline acetyltransferase-immunocytochemistry. These results suggest that cholinergic projections from basal forebrain neurons in mice cause vasodilation in the ipsilateral cerebral cortex by a combination of muscarinic and nicotinic mechanisms, as previously found in rats and cats. |
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Authors:
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Harumi Hotta; Sae Uchida; Fusako Kagitani; Naoki Maruyama |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-20 |
Journal Detail:
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Title: The journal of physiological sciences : JPS Volume: - ISSN: 1880-6562 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101262417 Medline TA: J Physiol Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Autonomic Neuroscience, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan, hhotta@tmig.or.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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