Document Detail

Control of cellular proliferation by the fibroblast and epidermal growth factors.
MedLine Citation:
PMID:  219349     Owner:  NLM     Status:  MEDLINE    
Recent studies on the effect of the fibroblast and epidermal growth factors (FGF and EGF, respectively) on the proliferation of ovarian cells and vascular endothelial cells are reviewed. During the ovarian cycle, luteal cells are derived from granulosa cells by a process of cytomorphosis. These two cell types thus allow a study of the changes that occur in growth control when one cell type is converted into another. Also described is the control of vascular endothelial cell proliferation by FGF (but not by EGF). We discuss the effects of FGF and EGF on cells derived from the embryonic ectoderm, mesoderm, and endoderm and examine the hypothesis that cellular specificity for various growth factors is conferred during embryo development. Finally, since antagonists of growth factors are probably as important as the mitogens in the overall control of cell proliferation, we review certain mechanisms and agents through which the mitogenic effect of FGF can be repressed, i.e., cell-cell interaction at confluence, trophic hormones, and a diffusible factor(s) from cartilage.
D Gospodarowicz; A L Mescher; C R Birdwell
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  National Cancer Institute monograph     Volume:  -     ISSN:  0083-1921     ISO Abbreviation:  Natl Cancer Inst Monogr     Publication Date:  1978 May 
Date Detail:
Created Date:  1979-06-11     Completed Date:  1979-06-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0216026     Medline TA:  Natl Cancer Inst Monogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  109-30     Citation Subset:  IM    
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MeSH Terms
Adrenocorticotropic Hormone / pharmacology
Capillaries / cytology
Cartilage / physiology
Cell Communication / drug effects
Cell Division / drug effects*
Cells, Cultured
Endothelium / drug effects
Epidermal Growth Factor / pharmacology*
Fibroblasts / physiology*
Granulosa Cells / drug effects
Growth Substances / pharmacology*
Luteal Cells / drug effects
Mesoderm / cytology
Peptides / pharmacology*
Reg. No./Substance:
0/Growth Substances; 0/Mitogens; 0/Peptides; 62229-50-9/Epidermal Growth Factor; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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