Document Detail

Control of cell volume in skeletal muscle.
MedLine Citation:
PMID:  19133959     Owner:  NLM     Status:  MEDLINE    
Regulation of cell volume is a fundamental property of all animal cells and is of particular importance in skeletal muscle where exercise is associated with a wide range of cellular changes that would be expected to influence cell volume. These complex electrical, metabolic and osmotic changes, however, make rigorous study of the consequences of individual factors on muscle volume difficult despite their likely importance during exercise. Recent charge-difference modelling of cell volume distinguishes three major aspects to processes underlying cell volume control: (i) determination by intracellular impermeant solute; (ii) maintenance by metabolically dependent processes directly balancing passive solute and water fluxes that would otherwise cause cell swelling under the influence of intracellular membrane-impermeant solutes; and (iii) volume regulation often involving reversible short-term transmembrane solute transport processes correcting cell volumes towards their normal baselines in response to imposed discrete perturbations. This review covers, in turn, the main predictions from such quantitative analysis and the experimental consequences of comparable alterations in extracellular pH, lactate concentration, membrane potential and extracellular tonicity. The effects of such alterations in the extracellular environment in resting amphibian muscles are then used to reproduce the intracellular changes that occur in each case in exercising muscle. The relative contributions of these various factors to the control of cell volume in resting and exercising skeletal muscle are thus described.
Juliet A Usher-Smith; Christopher L-H Huang; James A Fraser
Related Documents :
3616909 - Effect of hypothermia on cellular membrane function during low-flow extracorporeal circ...
20224659 - The role of exercise-induced myokines in muscle homeostasis and the defense against chr...
24748529 - High-intensity intermittent cycling increases purine loss compared with workload-matche...
20863269 - Exercise-induced decline in the density of lyve-1-positive lymphatic vessels in human s...
9421469 - Substrate availability limits human skeletal muscle oxidative atp regeneration at the o...
17417049 - Mitochondrial dysfunction: impact on exercise performance and cellular aging.
20599809 - The effect of exercise on trka in the contralateral hemisphere of the ischemic rat brain.
3021489 - Clinical evaluation of nedocromil sodium in asthma.
2725339 - Microvascular responses to chronic hypoxia by the chick chorioallantoic membrane: a mor...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-12-19
Journal Detail:
Title:  Biological reviews of the Cambridge Philosophical Society     Volume:  84     ISSN:  1469-185X     ISO Abbreviation:  Biol Rev Camb Philos Soc     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-05-18     Revised Date:  2014-10-14    
Medline Journal Info:
Nlm Unique ID:  0414576     Medline TA:  Biol Rev Camb Philos Soc     Country:  England    
Other Details:
Languages:  eng     Pagination:  143-59     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amphibians / physiology*
Cell Count
Cell Size
Membrane Potentials / physiology*
Muscle Cells / cytology*,  physiology
Muscle, Skeletal / cytology*
Physical Conditioning, Animal / physiology
Water-Electrolyte Balance / physiology*
Grant Support
BB/F023863/1//Biotechnology and Biological Sciences Research Council; //British Heart Foundation; //Wellcome Trust; //Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Interventions for treating oral mucositis for patients with cancer receiving treatment.
Next Document:  Testing co-evolutionary hypotheses over geological timescales: interactions between Mesozoic non-avi...