Document Detail


Control of cell proliferation within the human thymus. A very limited thymocyte subpopulation generates a suppressive activity.
MedLine Citation:
PMID:  2945726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is shown here that a minor subpopulation of the human thymus, representing 2-3% of the whole thymocyte population, can suppress proliferation of syngeneic or allogeneic thymocytes to various stimuli. In contrast, this suppressor cell population has no influence on the proliferative response of peripheral blood lymphocytes. This subpopulation was defined by its cell surface phenotype as CD3+, CD1-, 4-, 8- cells. Its suppressive activity is generated after concanavalin A (Con A) stimulation, but not after stimulation with phytohemagglutinin. In addition, the suppressive activity is not modified by extensive washes of Con A-stimulated cells with 1-O-methyl-alpha-D-glucopyranoside, a specific sugar for Con A. This suppressor cell population does not exert any detectable cytotoxic activity, nor does it act by consuming available interleukin 2 (IL 2). Rather, it prevents IL 2 receptor expression on thymic target cells. Since Con A might activate T cells by binding to molecules physiologically involved in T cell activation, particularly the CD3-T cell receptor complex, these data could be relevant to the regulation of normal thymic differentiation.
Authors:
C Gelin; L Boumsell; A Bernard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of immunology     Volume:  16     ISSN:  0014-2980     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-12-17     Completed Date:  1986-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1209-16     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antigens, Differentiation, T-Lymphocyte
Antigens, Surface / analysis
Child
Child, Preschool
Concanavalin A / pharmacology
Cytotoxicity, Immunologic
Humans
Infant
Interleukin-2 / metabolism
Lymphocyte Activation
Receptors, Immunologic / analysis
Receptors, Interleukin-2
T-Lymphocytes / classification*,  immunology
T-Lymphocytes, Regulatory / immunology*
Thymus Gland / cytology*
Chemical
Reg. No./Substance:
0/Antigens, Differentiation, T-Lymphocyte; 0/Antigens, Surface; 0/Interleukin-2; 0/Receptors, Immunologic; 0/Receptors, Interleukin-2; 11028-71-0/Concanavalin A

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