Document Detail


Control of cell identity in pancreas development and regeneration.
MedLine Citation:
PMID:  23622126     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The endocrine and exocrine cells in the adult pancreas are not static, but can change their differentiation state in response to injury or stress. This concept of cells in flux means that there may be ways to generate certain types of cells (such as insulin-producing β-cells) and prevent formation of others (such as transformed neoplastic cells). We review different aspects of cell identity in the pancreas, discussing how cells achieve their identity during embryonic development and maturation, and how this identity remains plastic, even in the adult pancreas.
Authors:
Ben Z Stanger; Matthias Hebrok
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Gastroenterology     Volume:  144     ISSN:  1528-0012     ISO Abbreviation:  Gastroenterology     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-29     Completed Date:  2013-06-20     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1170-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 AGA Institute. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult Stem Cells / metabolism,  pathology
Animals
Cell Differentiation* / genetics
Cell Lineage* / genetics
Cell Proliferation
Embryonic Stem Cells / metabolism,  pathology
Gene Expression Regulation, Developmental
Humans
Pancreas / embryology,  growth & development,  metabolism*,  pathology,  physiopathology
Pancreatic Diseases / genetics,  metabolism*,  pathology,  physiopathology,  therapy
Pancreatic Neoplasms / pathology,  physiopathology
Regeneration*
Signal Transduction* / genetics
Stem Cells / metabolism*,  pathology
Grant Support
ID/Acronym/Agency:
CA112537/CA/NCI NIH HHS; DK083111/DK/NIDDK NIH HHS; DK083355/DK/NIDDK NIH HHS; DP2 DK083111/DK/NIDDK NIH HHS; P30 DK063720/DK/NIDDK NIH HHS; R01 CA112537/CA/NCI NIH HHS; R01 DK083355/DK/NIDDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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