| Control of cell growth by the SCF and APC/C ubiquitin ligases. | |
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MedLine Citation:
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PMID: 19775879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ubiquitin-proteasome system plays key roles in the control of cell growth. The cell cycle, in particular, is highly regulated by the functions of the SCF and APC/C ubiquitin ligases, and perturbation of their function can result in tumorigenesis. Although the SCF and APC/C complexes are well established in growth control pathways, many aspects of their function remain unknown. Recent studies have shed light on the mechanism of SCF-mediated ubiquitination and new functions for the SCF complex and APC/C. Our expanding understanding of the roles of the SCF and APC/C complexes highlight the potential for targeted molecular therapies. |
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Authors:
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Jeffrey R Skaar; Michele Pagano |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-09-21 |
Journal Detail:
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Title: Current opinion in cell biology Volume: 21 ISSN: 1879-0410 ISO Abbreviation: Curr. Opin. Cell Biol. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-02 Completed Date: 2010-03-05 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8913428 Medline TA: Curr Opin Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 816-24 Citation Subset: IM |
Affiliation:
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Department of Pathology, NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / physiology Cell Cycle Proteins / genetics, metabolism Cullin Proteins Humans Models, Biological Proteasome Endopeptidase Complex / genetics, metabolism SKP Cullin F-Box Protein Ligases / genetics, metabolism* Signal Transduction Ubiquitin / genetics, metabolism Ubiquitin C / genetics, metabolism* Ubiquitin-Protein Ligases / genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM057587-12/GM/NIGMS NIH HHS; R01-GM057587/GM/NIGMS NIH HHS; R21 CA125173-02/CA/NCI NIH HHS; R21-CA125173/CA/NCI NIH HHS; R37 CA076584-12/CA/NCI NIH HHS; R37-CA076584/CA/NCI NIH HHS; //Howard Hughes Medical Institute; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/Cullin Proteins; 0/Ubiquitin; 0/Ubiquitin C; EC 3.4.25.1/Proteasome Endopeptidase Complex; EC 6.3.2.19/SKP Cullin F-Box Protein Ligases; EC 6.3.2.19/Ubiquitin-Protein Ligases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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