Document Detail


Control of cell growth: Rag GTPases in activation of TORC1.
MedLine Citation:
PMID:  23242467     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The target of rapamycin (TOR) is a central regulator controlling cell growth. TOR is highly conserved from yeast to mammals, and is deregulated in human cancers and diabetes. TOR complex 1 (TORC1) integrates signals from growth factors, cellular energy status, stress, and amino acids to control cell growth, mitochondrial metabolism, and lipid biosynthesis. The mechanisms of growth factors and cellular energy status in regulating TORC1 have been well established, whereas the mechanism by which amino acid induces TORC1 remains largely unknown. Recent studies revealed that Rag GTPases play a central role in the regulation of TORC1 activation in response to amino acids. In this review, we will discuss the recent progress in our understanding of Rag GTPase-regulated TORC1 activation in response to amino acids. Particular focus will be given to the function of Rag GTPases in TORC1 activation and how Rag GTPases are regulated by amino acids.
Authors:
Huirong Yang; Rui Gong; Yanhui Xu
Related Documents :
24189917 - Some monohydroxy tetradecanoic acid isomers as novel urease and elastase inhibitors and...
24040807 - Disruption of glutamate-glutamine-gaba cycle significantly impacts on suicidal behaviou...
23737257 - One-pot synthesis of an acid-labile amphiphilic triblock copolymer and its ph-responsiv...
24901717 - Effect of eicosapentaenoic acid on the expression of abcg1 gene in the human monocyte t...
9661277 - Pretreatment and biodegradability enhancement of dsd acid manufacturing wastewater.
3605607 - Western blotting of histones from acid-urea-triton- and sodium dodecyl sulfate-polyacry...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-16
Journal Detail:
Title:  Cellular and molecular life sciences : CMLS     Volume:  -     ISSN:  1420-9071     ISO Abbreviation:  Cell. Mol. Life Sci.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705402     Medline TA:  Cell Mol Life Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Cancer Institute, Shanghai Cancer Center, Fudan University, Shanghai, 200032, People's Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Tiny moments of great importance: The Marte Meo method applied in the context of early mother-infant...
Next Document:  Birth Order and Avuncular Tendencies in Samoan Men and Fa'afafine.