Document Detail


Control of cell fate by the formation of an architecturally complex bacterial community.
MedLine Citation:
PMID:  18381896     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bacteria form architecturally complex communities known as biofilms in which cells are held together by an extracellular matrix. Biofilms harbor multiple cell types, and it has been proposed that within biofilms individual cells follow different developmental pathways, resulting in heterogeneous populations. Here we demonstrate cellular differentiation within biofilms of the spore-forming bacterium Bacillus subtilis, and present evidence that formation of the biofilm governs differentiation. We show that motile, matrix-producing, and sporulating cells localize to distinct regions within the biofilm, and that the localization and percentage of each cell type is dynamic throughout development of the community. Importantly, mutants that do not produce extracellular matrix form unstructured biofilms that are deficient in sporulation. We propose that sporulation is a culminating feature of biofilm formation, and that spore formation is coupled to the formation of an architecturally complex community of cells.
Authors:
Hera Vlamakis; Claudio Aguilar; Richard Losick; Roberto Kolter
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Genes & development     Volume:  22     ISSN:  0890-9369     ISO Abbreviation:  Genes Dev.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-02     Completed Date:  2008-05-13     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  945-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bacillus subtilis / cytology,  genetics,  physiology*
Biofilms / growth & development*
Ecosystem
Extracellular Matrix / metabolism
Flow Cytometry
Gene Expression Regulation, Bacterial
Genetic Complementation Test
Mutation
Spores, Bacterial / genetics,  physiology
Grant Support
ID/Acronym/Agency:
GM18568/GM/NIGMS NIH HHS; GM58213/GM/NIGMS NIH HHS; R01 GM018568-36/GM/NIGMS NIH HHS; R01 GM058213-10/GM/NIGMS NIH HHS
Comments/Corrections

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