| Control of cell cycle and cell growth by molecular chaperones. | |
| | |
MedLine Citation:
|
PMID: 17957140 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cells adapt their size to both intrinsic and extrinsic demands and, among them, those that stem from growth and proliferation rates are crucial for cell size homeostasis. Here we revisit mechanisms that regulate cell cycle and cell growth in budding yeast. Cyclin Cln3, the most upstream activator of Start, is retained at the endoplasmic reticulum in early G(1) and released by specific chaperones in late G(1) to initiate the cell cycle. On one hand, these chaperones are rate-limiting for release of Cln3 and cell cycle entry and, on the other hand, they are required for key biosynthetic processes. We propose a model whereby the competition for specialized chaperones between growth and cycle machineries could gauge biosynthetic rates and set a critical size threshold at Start. |
| | |
Authors:
|
Martí Aldea; Eloi Garí; Neus Colomina |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-08-19 |
Journal Detail:
|
Title: Cell cycle (Georgetown, Tex.) Volume: 6 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2007 Nov |
Date Detail:
|
Created Date: 2007-11-12 Completed Date: 2007-12-31 Revised Date: 2008-09-23 |
Medline Journal Info:
|
Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
|
Languages: eng Pagination: 2599-603 Citation Subset: IM |
Affiliation:
|
Departament de Ciències Mèdiques Bàsiques, IRBLLEIDA, Universitat de Lleida, Lleida, Catalonia, Spain. marti.aaldea@cmb.udl.cat |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Cycle
/
physiology* Cell Enlargement* Cell Proliferation* Molecular Chaperones / physiology* Saccharomycetales / cytology*, growth & development*, physiology |
| Chemical | |
Reg. No./Substance:
|
0/Molecular Chaperones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways.
Next Document: Stimulus-specific transcriptional regulation within the p53 network.