Document Detail

Control of cardiogenesis by the notch pathway.
MedLine Citation:
PMID:  17418369     Owner:  NLM     Status:  MEDLINE    
In metazoans, the Notch pathway is one of the crucial pathways that regulate cell fates and tissue formation during development. Moreover, Notch has also been implicated in the regenerative capacity of adult self-renewing tissues. Notch signaling mediates local cell-cell communication via interaction of the Notch receptors with a membrane-bound ligand of the Delta-Serrate-LAG-2 family. Accumulating evidence suggests that aberrant Notch signaling is implicated in a variety of human diseases. In the heart, Notch controls several key processes during cardiac morphogenesis. In particular, Notch plays an important role in the commitment between the mesodermal and neuroectodermal lineages and seems to regulate cardiogenesis in mesodermal precursors.
Thierry Pedrazzini
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  17     ISSN:  1050-1738     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-09     Completed Date:  2007-07-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  83-90     Citation Subset:  IM    
Department of Medicine, University of Lausanne Medical School, CH-1011 Lausanne, Switzerland.
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MeSH Terms
Cell Communication / physiology
Cell Differentiation / physiology
Myocardium / cytology
Myocytes, Cardiac / cytology,  physiology*
Neovascularization, Physiologic
Receptors, Cell Surface / physiology
Receptors, Notch / physiology*
Regeneration / physiology
Signal Transduction / physiology*
Reg. No./Substance:
0/Receptors, Cell Surface; 0/Receptors, Notch

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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