Document Detail

Control of breathing in patients with neuromuscular diseases.
MedLine Citation:
PMID:  8472072     Owner:  NLM     Status:  MEDLINE    
We reviewed the studies devoted to investigate the control of breathing in patients with neuromuscular diseases. Neural respiratory drive has been assessed in terms of minute ventilation and mouth occlusion pressure (P0.1) in patients with several types of neuromuscular affections (amyotrophic lateral sclerosis, poliomyelitis and post-polio syndrome, Guillain Barré syndrome, muscular dystrophies, inflammatory muscle diseases). More recently we have used electromyographic activity of diaphragm to evaluate neural drive in patients with myasthenia gravis and muscular dystrophies. The results of these studies seem to indicate that patients with myasthenia gravis are not likely to have a decreased respiratory drive, the disorder in neuromuscular transmission being probably the reason for the apparent decrease in diaphragmatic neural activation during hypercapnic stimulation. Increase in neural afferent information from lung and/or rib cage might explain both the increased neural respiratory drive and the faster breathing observed in patients with neuromuscular disease.
G Scano; F Gigliotti; R Duranti; M Gorini; A Fanelli; G Marconi
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo     Volume:  48     ISSN:  1122-0643     ISO Abbreviation:  Monaldi Arch Chest Dis     Publication Date:  1993  
Date Detail:
Created Date:  1993-05-19     Completed Date:  1993-05-19     Revised Date:  2008-06-02    
Medline Journal Info:
Nlm Unique ID:  9307314     Medline TA:  Monaldi Arch Chest Dis     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  87-91     Citation Subset:  IM    
Istituto di Clinica Medica III, Università degli Studi di Firenze, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Motor Neuron Disease / physiopathology
Muscular Diseases / physiopathology
Neuromuscular Diseases / physiopathology*
Polyradiculoneuropathy / physiopathology
Respiration / physiology*
Comment In:
Monaldi Arch Chest Dis. 1993;48(1):60-1   [PMID:  8472067 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Control of breathing in chest wall diseases.
Next Document:  Evaluation of human diaphragm function.