| Control of breathing in newborn mice lacking the beta-2 nAChR subunit. | |
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MedLine Citation:
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PMID: 15450117 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To study the ventilatory and arousal/defence responses to hypoxia in newborn mutant mice lacking the beta2 subunit of the nicotinic acetylcholine receptors. METHODS: Breathing variables were measured non-invasively in mutant (n = 31) and wild-type age-matched mice (n = 57) at 2 and 8 days of age using flow barometric whole-body plethysmography. The arousal/defence response to hypoxia was determined using behavioural criteria. RESULTS: On day 2, mutant pups had significantly greater baseline ventilation (16%) than wild-type pups (P < 0.02). Mutant pups had a decreased hypoxic ventilatory declines. Arousal latency was significantly shorter in mutant than in wild-type pups (133 +/- 40 vs. 146 +/- 20 s, respectively, P < 0.026). However, the duration of movement elicited by hypoxia was shorter in mutant than in wild-type pups (14.7 +/- 5.9 vs. 23.0 +/- 10.7 s, respectively, P < 0.0005). Most differences disappeared on P8, suggesting a high degree of functional plasticity. CONCLUSION: The blunted hypoxic ventilatory decline and the shorter arousal latency on day 2 suggested that disruption of the beta2 nicotinic acetylcholine receptors impaired inhibitory processes affecting both the ventilatory and the arousal response to hypoxia during postnatal development. |
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Authors:
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S Dauger; E Durand; G Cohen; H Lagercrantz; J-P Changeux; C Gaultier; J Gallego |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta physiologica Scandinavica Volume: 182 ISSN: 0001-6772 ISO Abbreviation: Acta Physiol. Scand. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-09-28 Completed Date: 2005-01-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370362 Medline TA: Acta Physiol Scand Country: England |
Other Details:
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Languages: eng Pagination: 205-12 Citation Subset: IM |
Copyright Information:
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Copyright 2004 Scandinavian Physiological Society |
Affiliation:
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Laboratoire de Neurologie et Physiologie du Développement, INSERM E9935, Hôpital Robert-Debré, Boulevard Sérurier, Paris, France. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Anoxia / genetics, physiopathology Arousal / genetics, physiology Body Temperature / physiology Body Weight / physiology Mice Mice, Inbred C57BL Mice, Mutant Strains Plethysmography, Whole Body / methods Receptors, Nicotinic / genetics* Respiration / genetics* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Nicotinic; 0/nicotinic receptor beta2 |
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