Document Detail

Control of breathing in newborn mice lacking the beta-2 nAChR subunit.
MedLine Citation:
PMID:  15450117     Owner:  NLM     Status:  MEDLINE    
AIM: To study the ventilatory and arousal/defence responses to hypoxia in newborn mutant mice lacking the beta2 subunit of the nicotinic acetylcholine receptors. METHODS: Breathing variables were measured non-invasively in mutant (n = 31) and wild-type age-matched mice (n = 57) at 2 and 8 days of age using flow barometric whole-body plethysmography. The arousal/defence response to hypoxia was determined using behavioural criteria. RESULTS: On day 2, mutant pups had significantly greater baseline ventilation (16%) than wild-type pups (P < 0.02). Mutant pups had a decreased hypoxic ventilatory declines. Arousal latency was significantly shorter in mutant than in wild-type pups (133 +/- 40 vs. 146 +/- 20 s, respectively, P < 0.026). However, the duration of movement elicited by hypoxia was shorter in mutant than in wild-type pups (14.7 +/- 5.9 vs. 23.0 +/- 10.7 s, respectively, P < 0.0005). Most differences disappeared on P8, suggesting a high degree of functional plasticity. CONCLUSION: The blunted hypoxic ventilatory decline and the shorter arousal latency on day 2 suggested that disruption of the beta2 nicotinic acetylcholine receptors impaired inhibitory processes affecting both the ventilatory and the arousal response to hypoxia during postnatal development.
S Dauger; E Durand; G Cohen; H Lagercrantz; J-P Changeux; C Gaultier; J Gallego
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  182     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-28     Completed Date:  2005-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  205-12     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Scandinavian Physiological Society
Laboratoire de Neurologie et Physiologie du Développement, INSERM E9935, Hôpital Robert-Debré, Boulevard Sérurier, Paris, France.
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MeSH Terms
Animals, Newborn
Anoxia / genetics,  physiopathology
Arousal / genetics,  physiology
Body Temperature / physiology
Body Weight / physiology
Mice, Inbred C57BL
Mice, Mutant Strains
Plethysmography, Whole Body / methods
Receptors, Nicotinic / genetics*
Respiration / genetics*
Time Factors
Reg. No./Substance:
0/Receptors, Nicotinic; 0/nicotinic receptor beta2

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