| Control of beta globin genes. | |
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MedLine Citation:
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PMID: 17910027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The developmental changes in expression of the beta like genes from embryonic to adult stages of human life are controlled at least partially at the level of the promoter sequences of these genes and their binding factors, and competition for promoter specific interactions with the locus control region (LCR). In recent years, the control of beta globin genes has also been investigated at the level of chromatin structure involving the chemical modification of histones and their remodelling by DNA dependent ATPases (SMARCA) containing protein complexes. The role of intergenic RNA is also being investigated with renewed interest. Although a wealth of information on the structure/function relationship of the LCR and globin promoters has been gathered over more than two decades, the fundamental nature of the control of these genes at the molecular level is still not completely understood. In the following pages, we intend to briefly describe the progress made in the field and discuss future directions. |
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Authors:
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Milind C Mahajan; Subhradip Karmakar; Sherman M Weissman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Journal of cellular biochemistry Volume: 102 ISSN: 0730-2312 ISO Abbreviation: J. Cell. Biochem. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-25 Completed Date: 2008-02-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8205768 Medline TA: J Cell Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 801-10 Citation Subset: IM |
Copyright Information:
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(c) 2007 Wiley-Liss, Inc. |
Affiliation:
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Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatin DNA, Intergenic Epigenesis, Genetic Gene Expression Regulation, Developmental* Globins / genetics* Humans Locus Control Region |
| Grant Support | |
ID/Acronym/Agency:
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1P01 HL63357/HL/NHLBI NIH HHS; N01-HV-28186/HV/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chromatin; 0/DNA, Intergenic; 9004-22-2/Globins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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