| Control of autoimmunity by naturally arising regulatory CD4+ T cells. | |
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MedLine Citation:
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PMID: 14711059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Naturally acquired immunological self-tolerance is not entirely accounted for by clonal deletion, anergy, and ignorance. It is now well established that the T cell-repertoire of healthy individuals harbors self-reactive lymphocytes with a potential to cause autoimmune disease and these lymphocytes are under dominant control by a unique subpopulation of CD4+ T cells now called regulatory T cells. Efforts to delineate these Treg cells naturally present in normal individuals have revealed that they are enriched in the CD25+ CD4+ population. The identification of the CD25 molecule as a useful marker for naturally arising CD4+ regulatory T cells has made it possible to investigate many key aspects of their immunobiology, including their antigen specificities and the cellular/molecular pathways involved in their development and their mechanisms of action. Furthermore, reduction or dysfunction of the CD25+ CD4+ regulatory T cell population can be responsible for certain autoimmune diseases in humans. |
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Authors:
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Shohei Hori; Takeshi Takahashi; Shimon Sakaguchi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Advances in immunology Volume: 81 ISSN: 0065-2776 ISO Abbreviation: Adv. Immunol. Publication Date: 2003 |
Date Detail:
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Created Date: 2004-01-08 Completed Date: 2004-02-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370425 Medline TA: Adv Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 331-71 Citation Subset: IM |
Affiliation:
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Laboratory of Immunopathology, Research Center for Allergy and Immunology, The Institute for Physical and Chemical Research (RIKEN), Yokohama 230-0045, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoimmune Diseases / etiology, immunology Autoimmunity* CD4-Positive T-Lymphocytes / immunology* Chemokines / metabolism Cytokines / metabolism Disease Models, Animal Gene Expression Profiling Humans Lymphopenia / immunology Mice Mice, Transgenic Phenotype Receptors, Interleukin-2 / metabolism Self Tolerance T-Lymphocyte Subsets / immunology |
| Chemical | |
Reg. No./Substance:
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0/Chemokines; 0/Cytokines; 0/Receptors, Interleukin-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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