Document Detail

Control of arteriolar resistance in heart failure. Partial attenuation of specific phosphodiesterase inhibitor-mediated vasodilation by digitalis glycosides.
MedLine Citation:
PMID:  1728484     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The vasodilatory response to local specific type III phosphodiesterase inhibition with amrinone was evaluated before and immediately after local administration of digoxin in 14 patients with severe congestive heart failure (CHF). METHODS AND RESULTS: A 3F polyethylene catheter was inserted into the common femoral artery for drug administration and pressure monitoring. Mean blood flow velocity (MBFV) was continuously determined in the superficial femoral artery by transcutaneous Doppler ultrasonography. After intra-arterial administration of 10 mg amrinone, group MBFV increased from 7.7 +/- 1.4 to 16.0 +/- 2.1 cm/sec (p less than 0.05, n = 10). Local administration of 20 micrograms digoxin, which was infused over 20 minutes, did not alter group MBFV (i.e., 8.2 +/- 1.6 versus 7.6 +/- 1.5 cm/sec; p = NS, n = 10). The second administration of 10 mg amrinone, which immediately followed completion of local digoxin infusion, increased group MBFV but to a lesser extent than that produced by the first amrinone administration (i.e., 11.9 +/- 1.9 versus 16.0 +/- 2.1 cm/sec; p less than 0.05, n = 10). When placebo was administered instead of digoxin, group MBFV was similar after the first and second administrations of amrinone (i.e., 15.3 +/- 3.3 versus 15.6 +/- 3.8 cm/sec; p = NS, n = 4). CONCLUSIONS: Although local administration of digoxin did not significantly alter baseline vascular tone in patients with CHF, it substantially decreased the direct vasodilatory effect induced by specific type III phosphodiesterase with amrinone.
G Jondeau; M Klapholz; S D Katz; M Maher; M Galvao; P Levato; T H LeJemtel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation     Volume:  85     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-02-06     Completed Date:  1992-02-06     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  54-60     Citation Subset:  AIM; IM    
Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y.
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MeSH Terms
Aged, 80 and over
Amrinone / pharmacology
Arterioles / physiopathology*
Blood Flow Velocity / drug effects
Digitalis Glycosides / pharmacology*
Digoxin / pharmacology
Femoral Artery / physiopathology
Heart Failure / physiopathology*
Hemodynamics / drug effects
Middle Aged
Phosphodiesterase Inhibitors / pharmacology*
Vascular Resistance* / drug effects
Vasodilation / drug effects*
Reg. No./Substance:
0/Digitalis Glycosides; 0/Phosphodiesterase Inhibitors; 20830-75-5/Digoxin; 60719-84-8/Amrinone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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