Document Detail

Control of airway function during and after exercise in asthmatics.
MedLine Citation:
PMID:  9924724     Owner:  NLM     Status:  MEDLINE    
Control of airway function during and after exercise in asthmatics. Med. Sci. Sports Exerc., Vol. 31, No. 1 (Suppl.), pp. S4-S11, 1999. In asthmatics, airway function can be quite variable during exercise depending on the level of exercise intensity, the duration of exercise, and whether the exercise is at constant load or variable in intensity. Airway diameter can be affected by activity of parasympathetic and sympathetic nerves, by systemic mediators such as catecholamines, and by local mediators such as histamine or leukotrienes. Asthmatic airways are populated with more inflammatory cells than normal airways, and bronchoconstrictor mediator release from these cells is probably caused by drying of the mucosa during and after periods of increased ventilation. There are a few bronchodilating mediators present in both asthmatic and normal airways that could protect against this bronchoconstriction, including prostaglandin PGE2 and nitric oxide. Although it is clear that many of the inflammatory mediators play a role in causing bronchoconstriction after exercise, the role of either bronchoconstrictor or bronchodilator mediators in controlling airway function during exercise has yet to be resolved. In addition, the mechanical interaction between lung parenchyma and airways may provide a bronchodilating influence. In conclusion, the variability in airway function during exercise in asthmatics could be caused by balance among various bronchodilator and bronchoconstrictor mediators, but it may also reflect a mechanical effect of varying levels of ventilation.
K C Beck
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  31     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-03-24     Completed Date:  1999-03-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S4-11     Citation Subset:  IM; S    
Mayo Clinic and Foundation, Rochester, MN 55905, USA.
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MeSH Terms
Asthma / physiopathology*
Bronchoconstriction / physiology
Exercise / physiology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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