| Control of acute aortic dissection. | |
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MedLine Citation:
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PMID: 1138395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An experimental model of acute aortic dissection has been designed in an effort to examine myocardial contractility and systolic arterial pressure as factors influencing the progression of dissection. Thirty mongrel dogs divided into three experimental groups underwent left thoracotomy and construction of a standard intimal tear in the proximal descending aorta. Nine of ten animals in the control group showed progression of the aortic dissection a mean of 81.5 percent of the distance from the aortotomy to the celiac axis. Group II consisted of ten dogs pretreated with propranolol. The myocardial contractility (dp/dt) was significantly depressed in this group without change in systolic pressure. However, progression of dissection occurred in nine of ten animals as in the control group. In Group III, ten dogs were pretreated with trimethaphan lowering the systolic blood pressure to 90 mm. Hg and depressing the dp/dt to levels equal to those of Group II. There was no progression of aortic dissection in any of the animals in this group. The results indicate that, under these experimental conditions, depression of myocardial contractility alone has no inhibitory effect on the progression of dissection. When controlled hypotension is added to myocardial depression, aortic dissection is inhibited completely. |
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Authors:
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W I Carney; H F Rheinlander; R J Cleveland |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Surgery Volume: 78 ISSN: 0039-6060 ISO Abbreviation: Surgery Publication Date: 1975 Jul |
Date Detail:
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Created Date: 1975-09-09 Completed Date: 1975-09-09 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 114-20 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / surgery Aortic Aneurysm / drug therapy*, therapy Blood Pressure / drug effects* Depression, Chemical Disease Models, Animal Dogs Hypotension / chemically induced Hypotension, Controlled Myocardial Contraction / drug effects* Premedication Propranolol / pharmacology, therapeutic use Trimethaphan / pharmacology, therapeutic use |
| Chemical | |
Reg. No./Substance:
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525-66-6/Propranolol; 7187-66-8/Trimethaphan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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