| Control and activity of type-1 serine/threonine protein phosphatase during the cell cycle. | |
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MedLine Citation:
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PMID: 8541514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The first part of this discourse will serve as a compendium of selected aspects of PP1 activity and control during the cell cycle. The latter sections will focus on the mammalian cell cycle dependent activity of PP1 on the negative growth regulatory product of the retinoblastoma susceptibility gene, pRB. The purpose here is to suggest one possible mechanism to explain how this phosphatase can effect cell cycle progression. An argument is made for PP1 playing an indirect role in regulating cell cycle progression by modulating the growth suppressive activity of pRB. |
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Authors:
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J W Ludlow; D A Nelson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Seminars in cancer biology Volume: 6 ISSN: 1044-579X ISO Abbreviation: Semin. Cancer Biol. Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1996-02-13 Completed Date: 1996-02-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9010218 Medline TA: Semin Cancer Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 195-202 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Rochester School of Medicine and Dentistry, NY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / physiology* Genes, Retinoblastoma Phosphoprotein Phosphatases / metabolism, physiology* Phosphorylation Phosphotransferases / physiology Substrate Specificity |
| Grant Support | |
ID/Acronym/Agency:
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CA11198/CA/NCI NIH HHS; CA56940/CA/NCI NIH HHS; DE07202/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 2.7.-/Phosphotransferases; EC 3.1.3.16/Phosphoprotein Phosphatases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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