Document Detail

Control of RNA processing by a large non-coding RNA over-expressed in carcinomas.
MedLine Citation:
PMID:  21266177     Owner:  NLM     Status:  MEDLINE    
RNA processing is vital for the high fidelity and diversity of eukaryotic transcriptomes and the encoded proteomes. However, control of RNA processing is not fully established. Σ RNA is a class of conserved large non-coding RNAs (murine Hepcarcin; human MALAT-1) up-regulated in carcinomas. Using antisense technology, we identified that RNA post-transcriptional modification is the most significant global function of Σ RNA. Specifically, processing of the pre-mRNAs of genes including Tissue Factor and Endoglin was altered by hydrolysis of Σ RNA/MALAT-1. These results support the hypothesis that Σ RNA/MALAT-1 is a regulatory molecule exerting roles in RNA post-transcriptional modification.
Rui Lin; Manami Roychowdhury-Saha; Chris Black; Andrew T Watt; Eric G Marcusson; Susan M Freier; Thomas S Edgington
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Publication Detail:
Type:  Journal Article     Date:  2011-01-23
Journal Detail:
Title:  FEBS letters     Volume:  585     ISSN:  1873-3468     ISO Abbreviation:  FEBS Lett.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-15     Completed Date:  2011-04-01     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  671-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
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MeSH Terms
Alternative Splicing
Antigens, CD / genetics,  metabolism
Carcinoma / metabolism*
Cells, Cultured
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
HeLa Cells
Nuclear Proteins / metabolism
Oligonucleotide Array Sequence Analysis
Oligonucleotides, Antisense
RNA Precursors / metabolism
RNA Processing, Post-Transcriptional*
RNA, Long Untranslated
RNA, Neoplasm / metabolism*
RNA, Untranslated / antagonists & inhibitors,  genetics,  metabolism*
RNA-Binding Proteins / metabolism
Receptors, Cell Surface / genetics,  metabolism
Thromboplastin / genetics,  metabolism
Grant Support
P01 HL016411-34/HL/NHLBI NIH HHS; T32 CA075924-09/CA/NCI NIH HHS
Reg. No./Substance:
0/Antigens, CD; 0/ENG protein, human; 0/MALAT1 long non-coding RNA, human; 0/Malat1 long non-coding RNA, mouse; 0/Nuclear Proteins; 0/Oligonucleotides, Antisense; 0/RNA Precursors; 0/RNA, Long Untranslated; 0/RNA, Neoplasm; 0/RNA, Untranslated; 0/RNA-Binding Proteins; 0/Receptors, Cell Surface; 170974-22-8/serine-arginine-rich splicing proteins; 9035-58-9/Thromboplastin

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